A case report: HER2 targeted therapy in colorectal cancer

Colorectal cancer (CRC) is a malignant tumor arising from the inner lining of the colon or rectum and is the third most common cancer and the third leading cause of cancer-related deaths in the United States. This article reports two cases of heavily pretreated metastatic CRC (mCRC) with HER2 overexpression who achieved a remarkable clinical response to trastuzumab plus pertuzumab.