A total synthesis of cyclodepsipeptide [Leu]6-aureobasidin K using combination of solid- and solution-phase

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Nội dung Text: A total synthesis of cyclodepsipeptide [Leu]6-aureobasidin K using combination of solid- and solution-phase

A total synthesis of cyclodepsipeptide [Leu]6-aureobasidin K using combination of solid- and solution-phase Andi Rahima, Ace Tatang Hidayata,b, Nurlelasaria, Desi Harnetia, Unang Supratmana,b, and Rani Maharania,b,* a Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, West Java, Indonesia b Laboratorium Sentral, Universitas Padjadjaran, Jatinangor, West Java, Indonesia * Corresponding email : r.maharani@unpad.ac.id Figure S1. Spectrum FT-IR of (R)-2-hydroxy-3-methylbutanoic acid 5
Figure S2. 1H-NMR (500 MHz in CD3OD) of (R)-2-hydroxy-3-methylbutanoic acid 5
Figure S3. Spectrum FT-IR of (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)oxy)-3-methylbutanoic acid 7
O OH O O O Figure S4. 1H-NMR (500 MHz in CDCl3) of (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)oxy)-3-methylbutanoic acid 7 Figure S5. 13C-NMR (125 MHz in CDCl3) (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)oxy)-3-methylbutanoic acid 7
Figure S6. Analytical RP-HPLC chromatogram of [Leu]6-Aureobasidin K 1 Conditions: Eluent : ACN:water (Gradient, 20-80%) 13 minutes λ 240 nm, v = 1 mL/min Stationary phase : LiChrosper C-18, PDA detectores Retention times : 6.49 min Figure S7. HR-TOF-MS-ES+ spectrum of [Leu]6-Aureobasidin K 1 Calculated mass : 1093.6673 [C59H90N8O10 + Na+]
Figure S8. 1H-NMR (500 MHz in CD3OD) of [Leu]6-Aureobasidin K 1