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Báo cáo khoa học: Phosphorylation of hormone-sensitive lipase by protein kinase A in vitro promotes an increase in its hydrophobic surface area

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:11

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Hormone-sensitive lipase (EC 3.1.1.79; HSL) is a key enzyme in the mobili-zation of fatty acids from stored triacylglycerols. HSL activity is controlled by phosphorylation of at least four serines. In rat HSL, Ser563, Ser659 and Ser660 are phosphorylated by protein kinase A (PKA)in vitro as well asin vivo, and Ser660 and Ser659 have been shown to be the activity-controlling sites in vitro.

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Nội dung Text: Báo cáo khoa học: Phosphorylation of hormone-sensitive lipase by protein kinase A in vitro promotes an increase in its hydrophobic surface area

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