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báo cáo khoa hoc : Rate, affinity and calcium dependence of nitric oxide synthase isoform binding to the primary physiological regulator calmodulin

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:12

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Using interferometry-based biosensors the binding and release of endothe-lial and neuronal nitric oxide synthase (eNOS and nNOS) from calmodulin (CaM) was measured. In both isoforms, binding to CaM is diffusion lim-ited and within approximately three orders of magnitude of the Smolu-chowski limit imposed by orientation-independent collisions.

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Nội dung Text: báo cáo khoa hoc : Rate, affinity and calcium dependence of nitric oxide synthase isoform binding to the primary physiological regulator calmodulin

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