Chapter 015. Headache (Part 6)
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Positron emission tomography (PET) activation in migraine. In spontaneous attacks of episodic migraine (A) there is activation of the region of the dorsolateral pons (intersection of dark blue lines); an identical pattern is found in chronic migraine (not shown). This area, which includes the noradrenergic locus coeruleus, is fundamental to the expression of migraine. Moreover, lateralization of changes in this region of the brainstem correlates with lateralization of the head pain in hemicranial migraine; the scans shown in panels B and C are of patients with acute migraine headache on the right and left side, respectively. (From S Afridi et...
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