Chapter 054. Skin Manifestations of Internal Disease (Part 3)
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Drug-induced erythroderma (exfoliative dermatitis) may begin as an exanthematous (morbilliform) eruption (Chap. 56) or may arise as diffuse erythema. A number of drugs can produce an erythroderma, including penicillins, sulfonamides, carbamazepine, phenytoin, gold, allopurinol, and zalcitabine. Fever and peripheral eosinophilia often accompany the eruption, and there may also be facial swelling, hepatitis, and allergic interstitial nephritis; this constellation is frequently referred to as drug reaction with eosinophilia and systemic symptoms (DRESS). In addition, reactions to anticonvulsants can lead to a pseudolymphoma syndrome (with adenopathy and circulating atypical lymphocytes), while reactions to allopurinol may be accompanied by gastrointestinal bleeding. ...
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