Chapter 105. Malignancies of Lymphoid Cells (Part 12)

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Table 105-10 Clinical Characteristics of Patients with Common Types of Non-Hodgkin's Lymphomas (NHL) Dis ease edian Age, years M Fre quency in tage S B one B Gastro intestinal Survi Children Male I/II vs Sympt Marro Tract III/IV, oms, % % w Involvement, ving 5 years Involve % ment, % B 6 Rar 9 3 7 3 cell chronic lymphocyt ic leukemia/ small lymphocyt ic lymphoma 5 e 3 vs 91 3 2 1 Ma ntle cell 3 6 e Rar 4 2 0 vs 80 8 2 4 6 9 7 lymphoma Ext ranodal marginal zone cell lymphoma of MALT B 0 6 e Rar 8 6 7 vs 33 9 1 4 1 50 4 type Fol licular lymphoma 9 5 e Rar 2 3 3 vs 67 8 2 2 4 4 2 Dif fuse large 4 B cell 6 % ~25 of 5 5 4 vs...

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Chapter 105. Malignancies of Lymphoid Cells (Part 12) Table 105-10 Clinical Characteristics of Patients with Common Types of Non-Hodgkin's Lymphomas (NHL) Dis M Fre S B B Gastro ease edian quency in tage one intestinal Age, Children Male I/II vs Sympt Marro Tract Survi years III/IV, oms, w Involvement, ving % % Involve % 5 ment, years % B 6 Rar 9 3 7 3
cell 5 e 3 vs 91 3 2 1 chronic lymphocyt ic leukemia/ small lymphocyt ic lymphoma Ma 6 Rar 2 2 6 9 ntle cell 3 e 4 0 vs 80 8 4 7 lymphoma Ext 6 Rar 6 1 1 50 ranodal 0 e 8 7 vs 33 9 4 4 marginal zone B cell lymphoma of MALT
type Fol 5 Rar 3 2 4 4 licular 9 e 2 3 vs 67 8 2 2 lymphoma Dif 6 ~25 5 3 1 18 fuse large 4 % of 5 4 vs 46 3 6 6 B cell childhood lymphoma NHL Bur 3 ~30 6 2 3 11 kitt's 1 % of 9 2 vs 38 2 3 5 lymphoma childhood NHL Pre 2 ~40 1 2 5 4 cursor T8 % of 4 1 vs 89 1 0 6 cell childhood lymphobla NHL stic
lymphoma An 3 Co 5 5 1 9 aplastic 4 mmon 9 1 vs 49 3 3 7 large T/null cell lymphoma Per 6 ~5 2 5 3 15 ipheral T 1 % of 5 0 vs 80 0 6 5 cell non- childhood Hodgkin's NHL lymphoma Note: MALT, mucosa-associated lymphoid tissue. The diagnosis of typical B cell CLL is made when an increased number of circulating lymphocytes (i.e., >4 x 109/L and usually >10 x 109/L) is found (Fig. 105-6) that are monoclonal B cells expressing the CD5 antigen. Finding bone marrow infiltration by the same cells confirms the diagnosis. The peripheral blood smear in such patients typically shows many "smudge" or "basket" cells, nuclear remnants of cells damaged by the physical shear stress of making the blood smear.
If cytogenetic studies are performed, trisomy 12 is found in 25–30% of patients. Abnormalities in chromosome 13 are also seen.