Chapter 108. Hematopoietic Cell Transplantation (Part 5)
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Graft-versus-Host Disease GVHD is the result of allogeneic T cells that were either transferred with the donor's stem cell inoculum or develop from it, reacting with antigenic targets on host cells. GVHD developing within the first 3 months posttransplant is termed acute GVHD, while GVHD developing or persisting beyond 3 months posttransplant is termed chronic GVHD. Acute GVHD most often first becomes apparent 2–4 weeks posttransplant and is characterized by an erythematous maculopapular rash; persistent anorexia or diarrhea, or both; and by liver disease with increased serum levels of bilirubin, alanine and aspartate aminotransferase, and alkaline phosphatase. ...
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