Chapter 128. Pneumococcal Infections (Part 6)
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Pneumococcal Infections: Treatment Antibiotic Susceptibility β-Lactam antibiotics, the cornerstone of therapy for serious pneumococcal infection, bind covalently to the active site and thereby block the action of enzymes (endo-, trans-, and carboxypeptidases) needed for cell-wall synthesis. Because these enzymes were identified by their reaction with radiolabeled penicillin, they are called penicillin-binding proteins. Until the late 1970s, virtually all clinical isolates of S. pneumoniae were susceptible to penicillin (i.e., were inhibited in vitro by concentrations of ...
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