Differential behaviour of normal, transformed and Fanconi’s anemia lymphoblastoid cells to modeled microgravity

Cuccarolo et al. Journal of Biomedical Science 2010, 17:63 http://www.jbiomedsci.com/content/17/1/63 Whether microgravity might influence tumour growth and carcinogenesis is still an open issue. It is not clear also if and how normal and transformed cells are differently solicited by microgravity. The present study was designed to verify this issue. Methods: Two normal, LB and HSC93, and two transformed, Jurkat and 1310, lymphoblast cell lines were used as representative for the two conditions. Two lymphoblast lines from Fanconi’s anemia patients group A and C (FA-A and FA-C, respectively), along with their isogenic corrected counterparts (FA-A-cor and FA-C-cor) were also used. Cell...