Gas Chromatography and Supercritical Fluid Chromatography

Gas chromatography – chromatography using a gas as the mobile phase and a solid/liquid as a stationary phase – In GC, the analytes migrate in the gas phase, so their boiling point plays a role – GC is generally applicable to compounds with masses up to about 500 Da and with ~60 torr vapor pressure at room temp (polar functional groups are trouble) Supercritical fluid chromatography – chromatography using a supercritical fluid as the mobile phase and a solid/liquid as a stationary phase – In SFC, the analytes are solvated in the supercritical fluid – SFC is applicable to a much wider range of molecules...