Anti-cancer

Flavonoids, a diverse group of secondary metabolites, are known for their health-promoting properties, including antioxidant, anti-inflammatory, and anticancer activities. Phyllanthus amarus is a medicinal plant with extensive traditional use and it is a rich source of flavonoids. This study aimed to elucidate the gene expression in flavonoid biosynthesis in P. amarus.

7p vifilm 11-10-2024 5 1   Download

A novel series of s-triazine derivatives was designed and screened for in silico an cancer activity in histone deacetylase 6 (HDAC6) target by molecular docking method using AutoDock Vina.

10p vifilm 11-10-2024 2 1   Download

The study's purpose is to in silico molecular docking of some new s-triazine derivatives for anticancer activity on the VEGFR2 receptor. Fifty s-triazine derivatives were screened for anticancer activity through inhibition of VEGFR2 (vascular endothelial growth factor receptor-2) by molecular docking method using AutoDock Vina software.

10p vifilm 11-10-2024 1 1   Download

Croton tonkinensis has been a focal point of medicinal research due to its rich phytochemical composition, particularly ent-kaurane diterpenoids. These compounds exhibit diverse biological activities, including anticancer, anti-inflammatory, anti-microbial, and osteogenic effects, which are explored in this review.

6p viyamanaka 06-02-2025 3 1   Download

Aim of the thesis: Synthesis of several derivatives and tubulysin analogues with the replacement of the amino acid methylpipecolic (Mep) at the N-terminal, replacing N,O-acetyl group by methyl group, and researching the role of tubuphenylalanine (Tup) group at the C-terminal.

26p extraenglish 24-05-2021 18 4   Download

Objective: Study on synthesis of nano dendrimer PAMAM with anticancer drugs carboplatin (CAR) and oxaliplatin (OXA) to reduce the toxicity of the drug to normal cells and improve the effectiveness on cancer cell destruction by increasing solubility, increasing drug storage capacity, targeting drugs passively.

27p extraenglish 24-05-2021 24 4   Download

Synthesis of several derivatives and tubulysin analogues with the replacement of the amino acid methylpipecolic (Mep) at the N-terminal, replacing N,O-acetyl group by methyl group, and researching the role of tubuphenylalanine (Tup) group at the C-terminal .

26p capheviahe27 23-02-2021 20 5   Download

To evaluate the anticancer effect of measles vaccine virus in combination with Nimotuzumab in vitro. To evaluate the anticancer effect of measles vaccine virus in combination with Nimotuzumab on nude mouse model with head and neck cancer (in vivo).

30p angicungduoc6 21-07-2020 37 4   Download

Obtained by the interaction of 2-amino-3,3-dichloroacrylonitrile and chlorosulphonyl isocyanate (Z)-(5-(dichloromethylene)-2-oxoimidazolidin-4-ylidene)sulfamoyl chloride reacts easily with excess of the aliphatic amine to form new (Z)-N-(5-(dichloromethylene)-2-oxoimidazolidin-4-ylidene)-N'-substituted sulfonamides.

12p tocectocec 25-05-2020 11 2   Download

Nuclear factor erythroid-2 related factor 2 (Nrf2) is a crucial transcription factor that regulates the expression of defensive antioxidants and detoxification enzymes in cells. In a previous study, we showed that expression of the Nrf2 gene is regulated by an epigenetic modification. Rauvolfia verticillata, a traditional Chinese herbal medicine widely used in China, possesses anticancer and antioxidant effects. In this study, we investigated how Nrf2 is epigenetically regulated by reserpine, the main active component in R. verticillata, in mouse skin epidermal JB6 P+ cells.

11p caothientrangnguyen 09-05-2020 19 2   Download

Hexadecylphosphocholine (HePC) is a synthetic lipid rep-resentative of a new group of antiproliferative agents, alkylphosphocholines (APC), which are promising candi-dates in anticancer therapy. Thus we have studied the action of HePC on the human hepatoblastoma cell line HepG2, which is frequently used as a model for studies into hepatic lipid metabolism.

7p research12 23-04-2013 43 2   Download

Imidazolium trans-imidazoledimethyl sulfoxide-tetrachlo-roruthenate (NAMI-A) is a novel ruthenium-containing experimental antimetastatic agent. Compelling evidence ascribes apivotal role toendothelial cells in theorchestration of tumor angiogenesis and metastatic growth, suggesting antiangiogenic therapy as an attractive approach for anticancer treatment.

10p tumor12 22-04-2013 46 2   Download

A large number of bioactive peptides have been isolated from amphibian skin secretions. These peptides have a variety of actions including antibiotic and anticancer acti-vities and the inhibition of neuronal nitric oxide synthase. We have investigated the structure–activity relationship of citropin 1.1, a broad-spectrum antibiotic and anticancer agent that also causes inhibition of neuronal nitric oxide synthase, by making a number of synthetically modified analogues.

13p tumor12 20-04-2013 38 3   Download

Plant flavonoids are polyphenolic compounds, commonly found in vegeta-bles, fruits and many food sources that form a significant portion of our diet. These compounds have been shown to interact with several ATP-bind-ing cassette transporters that are linked with anticancer and antiviral drug resistance and, as such, may be beneficial in modulating drug resistance. This study investigates the interactions of six common polyphenols; querce-tin, silymarin, resveratrol, naringenin, daidzein and hesperetin with the multidrug-resistance-associated proteins, MRP1, MRP4 and MRP5. ...

16p fptmusic 12-04-2013 41 2   Download

The Hsp90 molecular chaperone catalyses the final activa-tion step of many of themost important regulatory proteins of eukaryotic cells. The antibiotics geldanamycin and rad-icicol act as highly selective inhibitors of in vivo Hsp90 function through their ability to bindwithin the ADP/ATP binding pocket of the chaperone. Drugs based on these compounds are now being developed as anticancer agents, their administration having the potential to inactivate sim-ultaneously several of the targets critical for counteracting multistep carcinogenesis. ...

7p fptmusic 12-04-2013 48 3   Download

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is amember of theTNFfamilyandapotent inducer of apoptosis. TRAIL has been shown to effectively limit tumor growthin vivowithout detectable cytotoxic side-effects. Interferon (IFN)-coften modulates the anticancer activities of TNF family members including TRAIL. How-ever, little is known about the mechanism. To explore the mechanism, A549, HeLa, LNCaP, Hep3B andHepG2 cells were pretreated with IFN-c, and then exposed to TRAIL.

7p awards 05-04-2013 48 4   Download

The spontaneous acquisition of resistance to a variety of unrelated cytotoxic compounds has important implications in medical treatment of infectious diseases and anticancer therapy. In the yeast Saccharomyces cerevisiaethis pheno-menon is caused by overexpression of membrane efflux pumps and is called pleiotropic drug resistance. We have found that allelic forms of the genes for the transcription activators Pdr1p and Pdr3p, designated PDR1-12and PDR3-33,respectively, mediate resistance to diazaborine....

8p dell39 03-04-2013 39 3   Download

A number of drugs used in cancer chemotherapy induce oxidative stress by generation of oxygen free radicals (ROS) which might be an alternative mechanism for their cytotoxic effect via indu-cing apoptosis. In order to clarify the roles of antioxidants in chemotherapy, we investigated Quercetin (3,3’,4’,5,7-pentahyd-roxyflavone) and N-acetylcysteine (NAC) in different cell types treated with anticancer drugs. We studied cytotoxic activity of Topotecan alone and/or in combination with Quercetin in two human breast cancer cell lines, MCF-7 and MDA-MB-231. ...

7p inspiron33 26-03-2013 57 4   Download

Both microtubule destabilizer and stabilizer agents are important molecules in anticancer therapy. In particular, paclitaxel has been demonstrated to be effective for the treatment of ovarian, breast, and nonsmall cell lung carci-nomas. It has been shown that emergence of resistance against this agent correlates with an increase in the relative abundance of tubulin isoform bIII and that the more recently discovered IDN5390 can be effectively used once resistance has emerged.

10p inspiron33 25-03-2013 52 4   Download

The anticancer agents cisplatin and oxaliplatin are widely used in the treat-ment of human neoplasias. A genome-wide screen inSaccharomyces cere-visiae previously identified PPH3and PSY2among the top 20 genes conferring resistance to these anticancer agents. The mammalian ortho-logue of Pph3p is the protein serine⁄threonine phosphatase Ppp4c, which is found in high molecular mass complexes bound to a regulatory subunit R2.

13p inspiron33 25-03-2013 39 4   Download