Apoptotic
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. In vitro biological evaluation revealed the most active compound 4d with an inhibitory concentration of 42.87 μM against K562 and 47.42 μM on A549 cells. The anticancer activity of this naphthylidene isoxazolidinedione derivative was evident by cell cycle and apoptosis assays, which showed arrest of the G2/M phase (65.6%) of the K562 cells and induction of apoptosis with 21.47% apoptotic cells as compared to 0.2% of untreated cells, respectively.
10p dianmotminh02 03-05-2024 5 3 Download
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Trong nghiên cứu này, chiết xuất lá chanh tây bằng methanol (MLL) đã được đánh giá về hoạt tính chống ung thư của nó trong tế bào gốc ung thư vú MCF-7-SC kháng anoikis. MLL gây ra sự chết tế bào (apoptosis) trong MCF-7-SC được chứng minh bằng sự gia tăng sự hình thành cơ thể apoptotic, tăng số lượng tế bào G1, tăng tế bào dương tính với Annexin V, tăng tỷ lệ Bax / Bcl-2, kích hoạt protein của caspase-9 và caspase- 3, và sự thoái biến của protein poly (ADP-ribose) polymerase (PARP).
9p vicoachella2711 20-10-2020 28 0 Download
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The silver and gold nanoparticles were biosynthesized using leaves of a pharmacologically important plant Heliconia rostrata.
8p tocectocec 25-05-2020 6 0 Download
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Regulator of G protein signaling (RGS) proteins are gatekeepers regulating the cellular responses induced by G protein-coupled receptor (GPCR)-mediated activation of heterotrimeric G proteins. Specifically, RGS proteins determine the magnitude and duration of GPCR signaling by acting as a GTPase-activating protein for Gα subunits, an activity facilitated by their semiconserved RGS domain. The R7 subfamily of RGS proteins is distinguished by two unique domains, DEP/DHEX and GGL, which mediate membrane targeting and stability of these proteins.
13p caothientrangnguyen 09-05-2020 22 1 Download
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Rotaviruses (RVs) là nguyên nhân chủ yếu gây bệnh tiêu chảy cấp tính đối với trẻ em trên toàn thế giới nhưng lại không có thuốc điều trị đặc hiệu. Genipin là hợp chất tự nhiên trong cây dành dành có nhiều đặc tính dược lí như khả năng kháng viêm, kháng apoptotic, kháng vi sinh vật và khối u. Trong nghiên cứu này, hoạt chất genipin được thử nghiệm hoạt tính ức chế RVs trong điều kiện in-vitro.
6p cothumenhmong2 06-02-2020 49 0 Download
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Kim loại nặng cadmium là một tác nhân gây ô nhiễm môi trường liên quan tới các ngành công nghiệp nặng. Cadmium có thể được hấp thụ vào cơ thể con người qua đường tiêu hóa, hô hấp. Sự tích tụ cadmium trong cơ thể có thể gây nguy hiểm cho con người. Trong nghiên cứu ngày, chúng tôi khảo sát các tác động của cadmium trên nguyên bào sợi người trong quá trình nuôi cấy in vitro.
7p trinhthamhodang 24-10-2019 45 1 Download
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MicroRNAs (miRNAs) are small noncoding RNAs of about 19–25 nt that regulate gene expression posttranscriptionally under various cellular conditions, including apoptosis. The miRNAs involved in modulation of apoptotic events in T cells are partially known.
10p nutifooddau 27-01-2019 19 2 Download
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Previously, we demonstrated apoptotic cell death in the chorion laeve trophoblast layer of human fetal membrane tissues during the late stages of pregnancy, the progression of apoptosis during incubation in vitro, and its suppression by a low concentration of glucocorticoid hormones.
8p system191 01-06-2013 31 4 Download
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Hsp105aisoneof themajormammalianheat shockproteins that belongs to the HSP105/110 family, and is expressed at especially high levels in the brain as compared with other tissues in mammals. Previously, we showed that Hsp105a prevents stress-induced apoptosis in neuronal PC12 cells, and is a novel anti-apoptotic neuroprotective factor in the mammalian brain.
9p research12 23-04-2013 37 1 Download
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The oxidant function of pro-apoptotic protein Bax was investigated through heterologous expression in yeast. Direct measurements of fatty acid content show that Bax-expression induces oxidation of mitochondrial lipids. This effect is prevented by the coexpression of Bcl-xL. The oxi-dation actually could be followed on isolated mitochondria as respiration-induced peroxidation of polyunsaturatedcis-parinaric acid and on whole cells as the increase in the amount of thiobarbituric acid-reactiveproducts. ...
11p tumor12 22-04-2013 36 2 Download
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The structure–activity relations of a series of synthetic phenoxazone drugs with aminoalkyl side chains of variable length and different terminal groups were investigated by examining their biological activity and DNA complexation affinity. Biological activitywas determined fromtheir ability to induce apoptosis and cell cycle perturbations (activation of cell cycle checkpoints) using the human malignant MOLT-3 cell line. The thermodynamic parameters of drug– DNA complexation were determined by differential scan-ning calorimetry....
8p tumor12 20-04-2013 35 3 Download
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Monoclonal nonspecific suppressor factor (MNSF) is a cytokine with antigen nonspecific suppressive activity. MNSFb(a subunit of MNSF) is a 14.5kDa fusion protein consisting of a proteinwith 36%identitywith ubiquitin and ribosomal protein S30. The ubiquitin-like segment (Ubi-L) may be cleaved from MNSFbin the cytosol. Recently, we have observed that Ubi-L covalently binds to intracellular proteins in mitogen-activated murine T-helper type 2 clone, D.10 cells.
7p tumor12 20-04-2013 31 2 Download
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Exposure of mammalian cells to oxidant stress causes early (iron catalysed) lysosomal rupture followed by apoptosis or necrosis. Enhanced intracellular production of reactive oxygen species (ROS), presumably of mitochondrial origin, is also observed when cells are exposed to nonoxidant pro-apoptotic agonists of cell death. We hypothesized that ROS generation in this latter case might promote the apoptotic cascade and could arise from effects of released lysosomal materials on mitochondria.
9p tumor12 20-04-2013 30 1 Download
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The intracellular role of placental protein 17b (PP17b)/ TIP47has been controversial, because it is considered tobe a protein required for mannose 6-phosphate receptor trans-port from endosome totrans-Golgi as well as a neutral lipid droplet-associatedprotein.The similaritybetween theamino acid sequences of PP17 variants, adipophilin and perilipins, andbetween their gene structures indicate that PP17baswell as other alternatively spliced PP17 variants belong to the lipid storage droplet protein family, containing also some differentiation factors....
13p tumor12 20-04-2013 38 3 Download
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Here, we show that recombinant bovine PDE5A1 is pro-teolysedby recombinant caspase-3 inin vitroand transfected Cos-7 cells. In addition, the treatment of PDE5A1-trans-fectedCos-7andPC12cellswithstaurosporine, anapoptotic agent that activates endogenous caspase-3, also induced proteolysis and inactivation of PDE5A1. These findings suggest that there is specificity in the interaction between caspase-3 and PDE5A1 that requires application of an apoptotic stimulus.
9p tumor12 20-04-2013 54 4 Download
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BAP31 is a 28-kDa integral membrane protein of the endoplasmic reticulumwhose cytosolicdomaincontains two caspase recognition sites that are preferentially cleaved by initiator caspases,such as caspase-8. Recently,we reported that the caspase-resistant BAP31 inhibited Fas-mediated apoptotic membrane fragmentation and the release of cytochromec from mitochondria in KB epithelial cells (Nguyen M.,Breckenridge G.,Ducret A &Shore G. (2000) Mol. Cell.Biol.20,6731–6740).
8p tumor12 20-04-2013 32 3 Download
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Caspases are a conserved family of cysteine proteases. They play diverse roles in inflammatory responses and apoptotic pathways. Among the casp-ases is a subgroup whose primary function is to initiate apoptosis. Within their long prodomains, caspases-2, -9 and -12 contain a caspase activation and recruitment domain while caspases-8 and -10 bear death effector domains.
18p fptmusic 12-04-2013 41 2 Download
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The ciliated protozoanTetrahymenahas a unique apoptosis-like process, which is called programmed nuclear death (PND). During conjugation, the new germinal micro- and somatic macro-nuclei differentiate from a zygotic fertilized nucleus, whereas the old parental macronucleus degenerates, ensuring that only the new macronucleus is responsible for expression of the progeny genotype.
10p fptmusic 12-04-2013 29 1 Download
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Cancer cells develop strong anti-apoptotic signaling pathways and therefore escape many therapeutic regimens. Recognizing this feature of cancer cells, we have focused on two approaches: dis-arming the cancer cell from its anti-apoptotic weaponry [1, 2] and applying strategies aimed at enhancing pro-apoptotic signa-ling pathways selectively in the cancer cell [3]. The first goal has been achieved by developing highly selective Aktstatins [1, 2] that inhibit PKB 100 times better than PKA or PKC.
20p fptmusic 11-04-2013 33 2 Download
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Oxysterols, and particularly 7-ketocholesterol, appear to be strongly involved in the physiopathology of atherosclerosis. These molecules are suspected to be cytotoxic to the cells of the vascular wall and mono-cytes⁄macrophages, particularly by inducing apoptosis. Previous studies have demonstrated that 7-ketocholesterol-induced apoptosis is triggered by a sustained increase of cytosolic-free Ca 2+ , which elicits the mitochondrial pathway of apoptosis by activation of the calcium-dependent phosphatase calcineurin, leading to dephosphorylation of the ‘BH3 only’ protein BAD....
12p fptmusic 11-04-2013 32 1 Download