Approach to the patient

Triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer (BC). Treatment options for TNBC patients are limited and further insights into disease aetiology are needed to develop better therapeutic approaches. microRNAs’ ability to regulate multiple targets could hold a promising discovery approach to pathways relevant for TNBC aggressiveness.

19p vielonmusk 21-01-2022 10 0   Download

Although nivolumab (anti-programmed cell death-1 antibody) is a promising approach for advanced gastric cancer (AGC), the response rate remains limited. The aim of this multicenter retrospective study was to determine if clinical features could serve as prognostic factors of the efficacy of nivolumab in patients with AGC.

12p vielonmusk 21-01-2022 15 0   Download

To compare the result and safety of the Axxess biolimus-eluting stent with the second-generation drug-eluting stent (DES) in the treatment of bifurcation lesions. The result and safety of the Axxess biolimus-eluting stent were better than DES in treating bifurcation lesions. The present study suggests that the Axxess stent may represent a valid alternative approach for treating bifurcation lesions.

11p viwinter2711 18-10-2021 8 0   Download

The dissertation studies the quality of health care services by health insurance at district hospitals in Thai Nguyen province. The dissertation has summarized the theoretical and practical basis of the quality of health care services by health insurance. In addition to the traditional factors that constitute the quality of health care service by health insurance, approached from the patient's side according to the SERVPERF model, include Reliability; Responsiveness; Assurance; Empathy; Tangibles.

28p caygaocaolon10 19-02-2021 21 3   Download

Biotherapeutics (BTs), one of the fastest growing classes of drug molecules, offer several advantages over the traditional small molecule pharmaceuticals because of their relatively high specificity, low off-target effects, and biocompatible metabolism, in addition to legal and logistic advantages. However, their clinical utility is limited, among other things, by their high immunogenic potential and/or variable therapeutic efficacy in different patient populations.

7p caothientrangnguyen 09-05-2020 22 0   Download

Objectives: To assess results of transanal total mesorectal excision laparoscopic surgery for treatment of the middle and low rectal cancer. Subjects and method: Clinical intervention, prospective, follow-up study without comparison in 45 patients with middle and low rectal cancer underwent transanal total mesorectal excision in Gastrointestinal Surgery Department, 108 Millitary Central Hospital, from July 2017 to August 2018.

9p vixyliton2711 17-04-2019 23 1   Download

Head and neck squamous cell carcinoma (HNSCC) is the most common and most aggressive type of head and neck cancer. Current approaches for the treatment of HNSCC are not sufficient to increase the patient survival or to reduce the high recurrence rate.

12p nutifooddau 27-01-2019 24 2   Download

Guidelines and recommendations developed and/or endorsed by the American College of Rheumatology (ACR) are intended to provide guidance for particular patterns of practice and not to dictate the care of a particular patient.

15p tramnamcodon_01 28-03-2016 67 2   Download

The ACR considers adherence to these guidelines and recommendations to be voluntary, with the ultimate determination regarding their application to be made by the physician in light of each patient’s individual circumstances. Guidelines and recommendations are intended to promote beneficial or desirable outcomes but cannot guarantee any specific outcome.

16p tramnamcodon_01 28-03-2016 62 1   Download

Theb-amyloid peptide (Ab) is a major component of toxic amyloid plaques found in the brains of patients with Alzheimer’s disease.Abis liberated by sequential cleavage of amyloid precursor protein (APP) byb-andc-secre-tases.The level of Abdepends directly on the hydrolytic activity ofb-secretase.Therefore, b-secretase is an excel-lent target for drug design.An approach based on RNA-cleaving ribozymes was developed to control expression ofb-secretase.

9p tumor12 20-04-2013 36 3   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" An integrated approach to diagnosis and management of severe haemoptysis in patients admitted to the intensive care unit: a case series from a referral centre...

9p toshiba12 21-10-2011 50 3   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Characterization of the bronchodilatory dose response to indacaterol in patients with chronic obstructive pulmonary disease using modelbased approaches...

9p toshiba11 20-10-2011 50 3   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: A novel approach to measure the contribution of matrix metalloproteinase in the overall net proteolytic activity present in synovial fluids of patients with arthritis...

10p thulanh13 14-10-2011 40 3   Download

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Factors affecting the long-term response to tacrolimus in renal transplant patients: Pharmacokinetic and pharmacogenetic approach...

7p thulanh9 07-10-2011 58 5   Download

Over the past 50 years, Lifeline Hospital has proved its multifaceted response and services towards the patient satisfaction and quality. Now, the hospital management has initiated processmanagement strategies to get improved quality, costeffectiveness and on-line tracking and booking of doctors and specialists. To achieve this goal, management has decided to use a process-management approach to coordinate all the doctors in the panel, around the organization, towards "patient-centered care." Consider you to be a part of the team that implements the solution for designing the application. ...

2p vudung75 20-04-2011 89 6   Download

Experts favor echocardiographic evaluation of all patients with a clinical diagnosis of endocarditis; however, the test should not be used to screen patients with a low probability of endocarditis (e.g., patients with unexplained fever). An American Heart Association approach to the use of echocardiography for evaluation of patients with suspected endocarditis is illustrated in Fig. 118-4. A negative TEE when endocarditis is likely does not exclude the diagnosis but rather warrants repetition of the study in 7–10 days.

11p thanhongan 07-12-2010 60 4   Download

Sepsis with Skin Manifestations (See also Chap. 18) Maculopapular rashes may reflect early meningococcal or rickettsial disease but are usually associated with nonemergent infections. Exanthems are usually viral. Primary HIV infection commonly presents with a rash that is typically maculopapular and involves the upper part of the body but can spread to the palms and soles. The patient is usually febrile and can have lymphadenopathy, severe headache, dysphagia, diarrhea, myalgias, and arthralgias.

5p thanhongan 07-12-2010 82 2   Download

Purpura Fulminans (See also Chaps. 136 and 265) Purpura fulminans is the cutaneous manifestation of DIC and presents as large ecchymotic areas and hemorrhagic bullae. Progression of petechiae to purpura, ecchymoses, and gangrene is associated with congestive heart failure, septic shock, acute renal failure, acidosis, hypoxia, hypotension, and death. Purpura fulminans has been associated primarily with N. meningitidis but, in splenectomized patients, may be associated with S. pneumoniae and H. influenzae.

5p thanhongan 07-12-2010 86 2   Download

Necrotizing Fasciitis This infection may arise at a site of minimal trauma or postoperative incision and may also be associated with recent varicella, childbirth, or muscle strain. The most common causes of necrotizing fasciitis are group A streptococci alone (Chap. 130) and a mixed facultative and anaerobic flora (Chap. 119). Diabetes mellitus, peripheral vascular disease, and intravenous drug use are associated risk factors.

5p thanhongan 07-12-2010 78 2   Download

Brain Abscess (See also Chap. 376) Brain abscess often occurs without systemic signs. Almost half of patients are afebrile, and presentations are more consistent with a space-occupying lesion in the brain; 70% of patients have headache, 50% have focal neurologic signs, and 25% have papilledema. Abscesses can present as single or multiple lesions resulting from contiguous foci or hematogenous infection, such as endocarditis. The infection progresses over several days from cerebritis to an abscess with a mature capsule.

5p thanhongan 07-12-2010 71 2   Download