Closed domain

Transmission: the propagation of a signal, message, or other form of intelligence by any means such as optical fiber, wire, or visual means. Switching: selects the route to the desired destination that the transmitted signal travels by the closing of switches in either the space domain or the time domain or some combinations of the two.

78p vanmanh1008 24-06-2013 80 7   Download

Luận văn tập trung đưa giải pháp và xây dựng mô hình Chatbot ứng dụng trong miền đóng (closed domain) và có khả năng sinh ra các câu trả lời phù hợp với những câu hỏi, yêu cầu từ phía người dùng. Phần lớn các hệ thống Chatbot hiện nay triển khai trong thực tế thì phần lớn là được xây dựng trên mô hình truy xuất thông tin và được áp dụng trong những miền ứng dụng cụ thể.

83p capheviahe27 23-02-2021 48 9   Download

This study reports the identification and characterization of the regulatory subunit, TbRSU, of protein kinase A of the parasitic protozoon Trypanosoma brucei. TbRSU is coded for by a single copy gene. The protein contains an unusually long N-terminal domain, the pseudosubstrate site involved in binding and inactivation of the catalytic subunit, and two C-terminally located, closely spaced cyclic nucleotide binding domains.

10p system191 01-06-2013 40 4   Download

The estrogen receptor-related receptorc (ERRc/ERR3/ NR3B3) is an orphan member of the nuclear receptor superfamily closely related to the estrogen receptors. To explore the DNA binding characteristics, the protein–DNA interaction was studied in electrophoretic mobility shift assays (EMSAs). In vitro translated ERRc binds as a homodimer to direct repeats (DR) without spacing of the nuclear receptor half-site 5¢-AGGTCA-3¢(DR-0), to exten-dedhalf-sites, and to the inverted estrogen response element....

12p research12 23-04-2013 23 3   Download

NTPDase1 and NTPDase2 are two related plasma mem-brane-located enzymes involved in the extracellular degra-dation of nucleoside 5¢-tri- and -diphosphates. They differ regarding their hydrolysis ratios for ATP and ADP. Both enzymes have a predicted transmembrane domain close to the N- and C-terminus, respectively, connected by an extensive extracellular domain that carries the active site.We expressed the rat-derived enzymes inXenopus laevisoocytes and analyzed their quarternary structure.

8p fptmusic 16-04-2013 36 5   Download

Atomic models of the myosin motor domain with different bound nucleotides have revealed the open and closed con-formationsof the switch2 element [Geeves,M.A.&Holmes, K.C. (1999)Annu. Rev. Biochem.68, 687–728]. The two conformations are in dynamic equilibrium, which is con-trolled by the bound nucleotide. In the present work we attempted to characterize the flexibilityof themotor domain in the open and closed conformations in rabbit skeletal myosin subfragment 1.

11p fptmusic 12-04-2013 41 2   Download

The binding of several alkyl- and aryl-guanidines andN-hydroxyguanidines to the oxygenase domain of inducible NO-synthase (iNOSoxy) was studied by UV⁄Vis difference spectroscopy. In a very general manner, monosubsti-tuted guanidines exhibited affinities for iNOSoxy that were very close to those of the corresponding N-hydroxyguanidines. The highest affinities were observed for the natural substrates,l-arginine and N x -hydroxy-l-arginine (Kd at thelmlevel).

12p fptmusic 11-04-2013 33 2   Download

Sixgenes are homologs ofDrosophila sine oculisand encode transcription factors that are characterized by a conserved Six domain and homeo-domain. Of the six family members (Six1–Six6) in mice, Six1and Six4 show similar expression patterns during embryogenesis. Six1 –⁄ – mice show defective formation of various organs such as inner ear, nose, skeletal mus-cle, kidney and thymus, whereasSix4 –⁄ – mice show little anomaly in organo-genesis.

16p awards 06-04-2013 31 3   Download

The solution structure ofNereis diversicolorsarcoplasmic calcium-binding protein (NSCP) in the calcium-bound form was determined by NMR spec-troscopy, distance geometry and simulated annealing. Based on 1859 NOE restraints and 262 angular restraints, 17 structures were generated with a rmsd of 0.87 A ˚ from the mean structure. The solution structure, which is highly similar to the structure obtained by X-ray crystallography, includes two open EF-hand domains, which are in close contact through their hydrophobic surfaces....

15p awards 06-04-2013 55 3   Download

Mutations in the proteina-tropomyosin (Tm) can cause a disease known as familial hypertrophic cardiomyopathy. In order to understand how such mutations lead to protein dysfunction, three point mutations were introduced into cDNA encoding the human skeletal tropomyosin, and the recombinant Tms were produced at high levels in the yeast Pichia pastoris. Two mutations (A63V and K70T) were located in theN-terminal regionofTmandone (E180G)was located close to the calcium-dependent troponin T binding domain....

9p awards 05-04-2013 54 3   Download

The tissue-specific transcription factorsHNF1aandHNF1b are closely related homeodomain proteins conserved in vertebrate evolution. Heterozygous mutations in human HNF1b 1 but not inHNF1agenes are associated with kidney malformations. Overexpression of HNF1b in Xenopus embryos leads to defective pronephros development, while HNF1ahas no effect. We have defined the regions respon-sible for this functional difference between HNF1band HNF1ain transfected HeLa cells as well as in injected Xenopusembryos. ...

14p awards 05-04-2013 44 3   Download

Genetic screens inDrosophilahave revealed that the serine⁄threonine kinase Hippo (Hpo) and the scaffold protein Salvador participate in a pathway that controls cell proliferation and apoptosis. Hpo most closely resembles the pro-apoptotic mammalian sterile20 kinases 1 and 2 (Mst1 and 2), and Salvador (Sav) has a human orthologue hSav (also called hWW45).

13p inspiron33 25-03-2013 34 3   Download

Drosophila melanogasterXPG-like endonuclease (DmGEN) is a new cate-gory of nuclease belonging to the RAD2⁄XPG family. The DmGEN pro-tein has two nuclease domains (N and I domains) similar to XPG⁄class I nucleases; however, unlike class I nucleases, in DmGEN these two nuclease domains are positioned close to each other as in FEN-1⁄class II and EXO-1⁄ class III nucleases.

14p galaxyss3 21-03-2013 48 4   Download

The steroidogenic acute regulatory (StAR)-related lipid transfer (START) domains are found in a wide range of proteins involved in intracellular trafficking of cholesterol and other lipids. Among the START proteins are the StAR protein itself (STARD1) and the closely related MLN64 protein (STARD3), which both function in cholesterol movement.

13p media19 06-03-2013 37 3   Download

Src-family kinases (SFKs) play a pivotal role in growth factor signaling, mitosis, cell motility and invasiveness. In their basal state, SFKs maintain a closed autoinhibited conformation, where the Src homology 2 domain inter-acts with an inhibitory phosphotyrosine in the C-terminus.

17p vinaphone15 25-02-2013 28 3   Download

Human neuronal growth inhibitory factor (hGIF) is able to inhibit the out-growth of neurons. As compared with the amino acid sequences of metallo-thionein 1⁄2, hGIF contains two insertions: a Thr at position 5 and an acidic hexapeptide EAAEAE(55–60) close to the C-terminus. Moreover, all mammalian growth inhibitory factor sequences contain a conserved CPCP(6–9) motif.

12p viettel02 22-02-2013 35 1   Download

Two structures of monomeric methionyl-tRNA synthetase, fromMycobac-terium smegmatis, in complex with the ligands methionine⁄adenosine and methionine, were analyzed by X-ray crystallography at 2.3 A˚ and at 2.8 A˚ , respectively. The structures demonstrated the flexibility of the multidomain enzyme. A new conformation of the structure was identified in which the connective peptide domain bound more closely to the catalytic domain than described previously.

16p viettel02 19-02-2013 45 3   Download

Annals of Mathematics This paper is the third in a series where we describe the space of all embedded minimal surfaces of fixed genus in a fixed (but arbitrary) closed 3-manifold. In [CM3]–[CM5] we describe the case where the surfaces are topologically disks on any fixed small scale. Although the focus of this paper, general planar domains, is more in line with [CM6], we will prove a result here (namely, Corollary III.

51p tuanloccuoi 04-01-2013 47 9   Download

Argumentation has been traditionally the domain of rhetorics and logics, rather than linguistics. Since Aristotle’s time, scholars have studied how ideas are organized in different ways to make an argument. Aristotle was the first person who realized two main constituent of an argument, a Position, and its Justification. Later on Ad Herennium (862BC) expanded the argumentation structure to include five parts: a proposition, a reason, a proof of the reason, an embellishment and a resume.

89p chieu_mua 22-08-2012 89 25   Download

v Research Article Reaction-Diffusion in Nonsmooth and Closed Domains

28p dauphong18 09-03-2012 22 5   Download