Differentiation disease
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Osteosarcoma (OS) is a differentiation disease caused by the genetic and epigenetic differentiation of mesenchymal stem cells into osteoblasts. OS is a common, highly malignant tumor in children and adolescents. Fifteen to 20 % of the patients find distant metastases at their first visit.
13p vielonmusk 21-01-2022 21 0 Download
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It is a basic task in high-throughput gene expression profiling studies to identify differentially expressed genes (DEGs) between two phenotypes. RankComp, an algorithm, could analyze the highly stable withinsample relative expression orderings (REOs) of gene pairs in a particular type of human normal tissue that are widely reversed in the cancer condition, thereby detecting DEGs for individual disease samples measured by a particular platform.
11p vielonmusk 21-01-2022 12 0 Download
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Loss of prostate cancer differentiation or de-differentiation leads to an untreatable disease. Patient survival would benefit if this can be prevented or reversed. Cancer de-differentiation transforms luminal-like (differentiated) adenocarcinoma into less luminal-like and more stem-like (undifferentiated) small cell carcinoma through a sequential activation of stem cell transcription factors (scTF) POU5F1, LIN28A, SOX2 and NANOG.
13p vielonmusk 21-01-2022 11 0 Download
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Hepatocellular carcinoma (HCC) is one of the deadliest cancers. Research on HCC so far primarily focused on genes and provided limited information on genomic repeats, which constitute more than half of the human genome and contribute to genomic stability. In line with this, repeat dysregulation was significantly shown to be pathological in various cancers and other diseases. In this study, we aimed to determine the full repeat expression profile of HCC for the first time.
14p thiencuuchu 27-11-2021 21 3 Download
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According to gene enrichment analysis, PPAR pathway, cardiac muscle contraction, and cytokinecytokine receptor interaction were the most enriched pathways. Besides, the nuclear factor-κB signaling pathway and hematopoietic cell linage pathways were also enriched. Chronic obstructive pulmonary disease (COPD) is enriched among KEGG disease pathways. RT-qPCR assays confirmed the RNA-Seq results. This study opens a new window toward the biological functions of Bex2 in different systems.
12p thiencuuchu 27-11-2021 16 1 Download
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Document presentation of content: Introduction & key points, disease burden & endemicity, risk groups, diagnosis and differential diagnosis, management of strongyloidiasis, literature references, useful websites, queries and feedback from you.
15p vovanvovan2013 13-05-2016 41 1 Download
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The ultimate step in Alzheimer’s disease Abgeneration involves c-secretase, which releases Abfrom its membrane-bound precursor. Asimilar presenilin-dependent proteolytic activity is implicated in the release of theNotch intracellular domain. We have developed a novel assay forc-secretase activity based on green fluorescent protein detection. This involves cotransfection of a substrate-activator based on the amyloid precursor protein or the Notch sequence and a fluorescent reporter gene.
12p tumor12 20-04-2013 28 2 Download
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Neurons are highly polarized cells composed of two structurally and func-tionally distinct parts, the axon and the dendrite. The establishment of this asymmetric structure is a tightly regulated process. In fact, alterations in the proteins involved in the configuration of the microtubule lattice are fre-quent in neuro-oncologic diseases.
14p inspiron33 23-03-2013 37 3 Download
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Protein kinases drive the cellular signal transduction networks that underlie the regulation of growth, survival and differentiation. To repair the deregu-lations of signaling cascades that are associated with numerous disease states, therapeutic strategies, based on controlling aberrant protein kinase activity, are emerging.
9p viettel02 20-02-2013 39 2 Download
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Chitotriosidase (CHIT1) is a chitinase that is secreted by activated macro-phages. Plasma chitotriosidase activity reflects the presence of lipid-laden macrophages in patients with Gaucher disease. CHIT1 activity can be con-veniently measured using fluorogenic 4-methylumbelliferyl (4MU)–chitotri-oside or 4MU–chitobioside as the substrate, however, nonsaturating concentrations have to be used because of apparent substrate inhibition.
11p viettel02 20-02-2013 27 1 Download
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The S100 proteins are 10–12 kDa EF-hand proteins that act as central reg-ulators in a multitude of cellular processes including cell survival, prolifera-tion, differentiation and motility. Consequently, many S100 proteins are implicated and display marked changes in their expression levels in many types of cancer, neurodegenerative disorders, inflammatory and autoim-mune diseases.
13p viettel02 19-02-2013 34 1 Download
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Mutations in the alanine-glyoxylate aminotransferase gene (AGXT) are responsible for primary hyperoxaluria type I, a rare disease characterized by excessive hepatic oxalate production that leads to renal failure. A deeper understanding of the changes in the metabolic pathways secondary to the lack of AGXT expression is needed in order to explore substrate depletion as a therapeutic strategy to limit oxalate production in primary hyperoxal-uria type I.
9p viettel02 19-02-2013 42 1 Download
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Proteolytic processes in the extracellular matrix are a major influence on cell adhesion, migration, survival, differentiation and proliferation. The syndecan cell-surface proteoglycans are important mediators of cell spread-ing on extracellular matrix and respond to growth factors and other bio-logically active polypeptides.
14p viettel02 19-02-2013 42 3 Download
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The risk of acquiring variant Creutzfeldt–Jakob disease is closely related to polymorphism at codon 129 of the human prion gene, because almost all variant Creutzfeldt–Jakob disease patients are Met⁄Met homozygotes. Although animal transmission experiments corroborated this seeding dis-crimination, the origin of the differential seeding efficiency of the bovine prion seed for human codon 129 polymorphism remained elusive.
11p cosis54 09-12-2012 31 2 Download
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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Decreased health-related quality of life in disease-free survivors of differentiated thyroid cancer in Korea
10p panasonic05 23-12-2011 41 3 Download
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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Differential disease resistance response in the barley necrotic mutant nec1
10p panasonic02 14-12-2011 44 3 Download
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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Differential patterns of histone acetylation in inflammatory bowel diseases...
12p thulanh26 09-12-2011 63 5 Download
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: FitSNPs: highly differentially expressed genes are more likely to have variants associated with disease...
0p thulanh20 12-11-2011 51 3 Download
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Combination of lung ultrasound (a comet-tail sign) and N-terminal pro-brain natriuretic peptide in differentiating acute heart failure from chronic obstructive pulmonary disease and asthma as cause of acute dyspnea in prehospital emergency setting...
9p coxanh_8 05-11-2011 43 1 Download
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Adult onset lung disease following transient disruption of fetal stretch-induced differentiation...
13p toshiba12 20-10-2011 36 3 Download