Disease progression

Patients with Parkinson’s disease experience physical decline due to the disease’s relentless progression, which may cause them unable to perform activity daily living. This study aimed to explore some factors related to ADL and IADL dependencies among older people with Parkinson’s disease.

8p vihizuzen 26-05-2025 1 1   Download

There is a clear correlation between inflammatory outcome signs and adverse outcomes in patients after acute myocardial infarction. Periostin - an inflammatory biomarker in recent times promises to be an effective and necessary factor in predicting disease progression. This study described characteristics of serum periostin levels in patients with acute MI and some follow up results of this biomaker.

6p vihizuzen 26-05-2025 0 0   Download

Chronic liver disease has a high global burden and death toll. Early diagnosis is important to halt disease progression to cirrhosis, hepatocellular carcinoma, and eventually death. At present, there are many methods used for liver disease assessment, such as liver biopsy, elastography, serum biomarkers, and surrogate markers.

5p vihizuzen 26-05-2025 3 1   Download

Malignant or necrotizing otitis externa (MOE) is a severe infectious condition of the external ear canal. It is rare but has a high mortality rate due to complications such as osteomyelitis of the skull base and intracranial involvement. This report aims to analyze the clinical and paraclinical characteristics and progression of the disease to draw lessons for the diagnosis and treatment of this dangerous condition.

5p vihizuzen 26-05-2025 1 1   Download

In patients with end-stage chronic kidney failure, there are a number of disorders that cause bone damage. In particular, secondary hyperparathyroidism (SHPT) is related to chronic kidney failure, a calcium-phosphorus metabolism disorder that causes bone disorder.

6p viengfa 23-10-2024 4 1   Download

Acetylcholinesterase (AChE) has been one of the important and potential targets in the discovery, and development of new drugs for treating and slowing the progression of Alzheimer's disease (AD). This research suggests potential structural frameworks for synthesizing AChE inhibitor derivatives for treating AD.

11p vihyuga 04-03-2025 1 1   Download

Dental caries is the most prevalent chronic childhood disease with numerous predisposing factors. Salivary properties have been linked to progressive dental caries in previous studies. However, the role of these contributing factors in the management of dental caries in children remains insufficient. Thus, the investigation of salivary characteristics from different types of communities within a specific pediatric population is an obvious demand.

7p vinara 11-01-2025 5 1   Download

Anxiety disorder is one of the issue that affects the patient's physical and mental health and reduces the effectiveness of treatment. At the moment, patients with underlying conditions, particularly those with hypertension, are more likely to experience anxiety problems. This lessens quality of life, accelerates disease progression, exacerbates illness symptoms, and decreases treatment compliance rates.

7p vinara 11-01-2025 3 1   Download

Hepatitis B infection remains a global health problem, with progression to acute-chronic hepatitis, severe liver failure, and death making hepatitis B one of the most serious infections worldwide. The disease is most widely transmitted from an infected mother to her baby, after exposure to infected blood or body fluids or unsafe sexual contact.

6p viharuno 03-01-2025 3 2   Download

In patients with end-stage chronic kidney failure, there are a number of disorders that cause bone damage. In this article we present a case of secondary HPT causing facial and thoracic bone changes.

6p viharuno 03-01-2025 3 2   Download

Early prediction of ovarian cancer has not been given much attention, the application of combined models in clinical practice is not widespread, and the calculation of these models is still difficult due to the complexity and multiple variables.

8p viharuno 03-01-2025 4 2   Download

Schistosomiasis is an endemic disease in Egypt caused by the trematode Schistosoma which has different species. c the best known form of chronic disease with a wide range of clinical manifestations. The pathogenesis of schistosomiasis is related to the host cellular immune response. This leads to granuloma formation and neo angiogenesis with subsequent periportal fibrosis manifested as portal hypertension, splenomegaly and esophageal varices. Intestinal schistosomiasis is another well identified form of chronic schistosomal affection.

8p kethamoi1 17-11-2019 31 2   Download

Dystrobrevin is one of the intracellular components of the transmembrane dystrophin–glycoprotein complex (DGC). The functional role of this complex in normal and pathological situations has not yet been clearly established. Dystrobrevin disappears from the muscle membrane in Duchenne muscular dystrophy (DMD), which results from dystrophin mutations, as well as in limb girdle muscular dystrophies (LGMD), which results from mutations affecting other members of the DGC complex.

6p system191 01-06-2013 37 5   Download

Human amylin (hA) is a small fibrillogenic protein that is the major con-stituent of pancreatic islet amyloid, which occurs in most subjects with type-2 diabetes mellitus (T2Dm). There is growing evidence that hA toxic-ity towards islet b-cells is responsible for their gradual loss of function in T2Dm. Preventing hA-mediated cytotoxicity has been proposed as a route to halt the progression of this disease, although this has not yet been dem-onstratedin vivo.

11p fptmusic 12-04-2013 33 2   Download

Huntington’s disease (HD) is a progressive neurodegenerative disorder characterized by multifarious dysfunctional alterations including mitochon-drial impairment. In the present study, the formation of inclusions caused by the mutation of huntingtin protein and its relationship with changes in energy metabolism and with pathological alterations were investigated both in transgenic and 3-nitropropionic acid-treated mouse models for HD.

16p inspiron33 23-03-2013 39 6   Download

Oculopharyngeal muscular dystrophy (OPMD) is an autosomal dominant disease that usually manifests itself within the fifth decade. The most prom-inent symptoms are progressive ptosis, dysphagia, and proximal limb mus-cle weakness. The disorder is caused by trinucleotide (GCG) expansions in the N-terminal part of the poly(A)-binding protein 1 (PABPN1) that result in the extension of a 10-alanine segment by up to seven more alanines.

10p inspiron33 23-03-2013 53 4   Download

Exposure to quartz particles induces a pathological process named silicosis. Alveolar macrophages initiate the disease through their activation, which is the origin of the later dysfunctions. Ascorbic acid is known to selectively dissolve the quartz surface. During the reaction, ascorbic acid progressively disappears and hydroxyl radicals are generated from the quartz surface. These observations may be relevant to mammalian quartz toxicity, as sub-stantial amounts of ascorbic acid are present in the lung epithelium. ...

14p inspiron33 23-03-2013 42 4   Download

Dendritic cells can enhance the replication of HIV-1 in CD4 + lymphocytes through the interaction of the gp120 envelope protein with such molecules as dendritic cell-specific intercellular adhesion molecule-3-grabbing noninte-grin. The variable loops of gp120 have previously been shown to modulate the interaction of HIV-1 with its principal receptor CD4 and its various coreceptors, namely CCR5 and CXCR4.

15p inspiron33 23-03-2013 45 4   Download

Familial amyloidotic polyneuropathy (FAP) is an inherited autosomal dominant disease that is commonly caused by accumulation of deposits of transthyretin (TTR) amyloid around peripheral nerves. The only effective treatment for FAP is liver transplantation.

14p galaxyss3 21-03-2013 56 3   Download

Parkinson’s disease (PD) is a heterogeneous movement disorder character-ized by progressive degeneration of dopamine neurons in substantia nigra. We have previously presented genetic evidence for the possible involvement of alcohol and aldehyde dehydrogenases (ADH; ALDH) by identifying genetic variants in ADH1C and ADH4 that associate with PD.

12p galaxyss3 21-03-2013 37 4   Download