Hepatocellular carcinoma

Chronic liver disease has a high global burden and death toll. Early diagnosis is important to halt disease progression to cirrhosis, hepatocellular carcinoma, and eventually death. At present, there are many methods used for liver disease assessment, such as liver biopsy, elastography, serum biomarkers, and surrogate markers.

5p vihizuzen 26-05-2025 3 1   Download

Metabolic-Associated Fatty Liver Disease (MAFLD) is affecting approximately 24% of individuals and potentially leading to cirrhosis and hepatocellular carcinoma. This study aims to assess the prevalence of MAFLD in chronic obstructive pulmonary disease (COPD) patients and analyze their clinical characteristics.

8p vijiraiya 19-05-2025 1 1   Download

Bài viết trình bày đánh giá kết quả gần và thời gian sống thêm sau ghép gan ở bệnh nhân (BN) ung thư biểu mô tế bào gan (hepatocellular carcinoma - HCC) do viêm gan B tại Bệnh viện Hữu Nghị Việt Đức. Phương pháp nghiên cứu: Nghiên cứu hồi cứu, mô tả trên 48 BN được ghép gan tại Bệnh viện Hữu nghị Việt Đức từ tháng 5/2012 - 5/2022, thời gian theo dõi trung bình 51,5 ± 37,1 tháng.

10p vipanly 28-10-2024 2 1   Download

Bài viết trình bày ung thư biểu mô tế bào gan dạng sarcôm (Sarcomatoid Hepatocellular Carcinoma – SHCC) là một loại u gan nguyên phát ác tính hiếm gặp. Bên cạnh vùng biệt hoá biểu mô dạng tế bào gan rõ trên mô bệnh học, SHCC còn có vùng biệt hoá dạng sarcôm với các tế bào u hình thoi. SHCC thường tiến triển nhanh, dễ tái phát và di căn xa.

6p vimaito 28-03-2025 5 1   Download

Evaluate plasma microRNA-21 and microRNA-122 expression levels in hepatitis B virus-related hepatocellular carcinoma patients. Analyze the relationship between microRNA-21, microRNA-122 plasma with some clinical, subclinical and stage indicators in hepatitis B virus-related hepatocellular carcinoma patients.

27p gaocaolon7 18-09-2020 25 2   Download

Determining the frequency of genotype and allele of TNF-α – 308 and TGF-β1-509 in HCC patients with HBsAg (+). Analysing the association of TNF-α-308, TGF-β1-509 polymorphism with risk of HCC and some clinical and subclinical characteristics of HCC patients.

28p cothumenhmong6 17-07-2020 16 1   Download

Regulators of G protein signaling (RGS) proteins modulate G protein-coupled receptor (GPCR) signaling networks by terminating signals produced by active Gα subunits. RGS17, a member of the RZ subfamily of RGS proteins, is typically only expressed in appreciable amounts in the human central nervous system, but previous works have shown that RGS17 expression is selectively upregulated in a number of malignancies, including lung, breast, prostate, and hepatocellular carcinoma.

10p caothientrangnguyen 09-05-2020 14 1   Download

This research aiming to: Describing clinical and characteristics laboratory features and identifying HCV genotype on patients of HCC. Evaluating relationship between HCV genotypes and some clinical characteristics laboratory features,on patients of HCC.

27p slimzslimz 21-12-2019 33 9   Download

The project with objectives: Assessment of clinical characteristics, paraclinical tests, imaging diagnoses of HCC pateints with PVT. 2- analysis of imaging, histopathology and immunohistochemistry characteristics of PVT, and safe biopsic technic, supplemental survival time and involving factors in pateins with PVT.

27p slimzslimz 21-12-2019 64 7   Download

Document presentation of content: Global prevalence and incidence, HCC risk factors, primary care, cascades—a resource-sensitive approach, primary HCC prevention, secondary HCC prevention—surveillance, secondary HCC prevention—surveillance, tertiary HCC prevention—recurrence.

14p vovanvovan2013 13-05-2016 40 3   Download

Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) has attractedmuch attention because of its ability to kill tumour cells. In this study, we demonstrated that treatment of QGY-7703 cells with the combination of TRAIL and etoposide resulted in synergistic cytotoxic effects. In dissecting the mechanism underlying this syner-gistic effect, we found that treatment with etoposide alone resulted in the upregulation of Bax, while the level of trun-catedBid (tBid)wasunchanged.

11p fptmusic 16-04-2013 40 3   Download

HIP/PAP is a C-type lectin overexpressed in hepatocel-lular carcinoma (HCC). Pleiotropic biological activities have been ascribed to this protein, but little is known about the function of HIP/PAP in the liver. In this study, therefore, we searched for proteins interacting with HIP/PAP by screening a HCC cDNA expression library. We have identified the RIIa regulatory subunit of cAMP-dependent protein kinase (PKA) as a partner of HIP/PAP. HIP/PAP and RIIa were coimmunoprecipi-tated in HIP/PAP expressing cells. ...

9p awards 05-04-2013 32 4   Download

Pyruvate is located at a crucial crossroad of cellular metabolism between the aerobic and anaerobic pathways. Modulation of the fate of pyruvate, in one direction or another, can be important for adaptative response to hypoxia followed by reoxygenation.

11p media19 04-03-2013 42 3   Download

Hepatitis C virus is a human pathogen responsible for liver diseases includ-ing acute and chronic hepatitis, cirrhosis and hepatocellular carcinoma. Its high prevalence, the absence of a prophylactic vaccine and the poor effi-ciency of current therapies are huge medical problems. Since the discovery of the hepatitis C virus, our knowledge of its biology has been largely punctuated by the development of original models of research.

14p media19 04-03-2013 35 3   Download

Vitamin K2(menaquinone-4, MK-4) has been reported to induce apoptosis in hepatocellular carcinoma, leukemia and myelodysplastic syndrome cell lines. The effects of MK-4 on the development of arthritis have never been addressed thus far. In the present study, we investigated the effect of MK-4 upon the proliferation of rheumatoid synovial cells and the development of arthritis in collagen-induced arthritis.

7p media19 04-03-2013 31 4   Download

Urokinase-type plasminogen activator (uPA) and c-met play a major role in cancer invasion and metastasis. Evidence has suggested that uPA and c-met overexpression may be coordinated in human hepatocellular carci-noma (HCC). In the present study, to understand whether the expression of these genes might be coregulated by specific microRNAs (miRs) in human cells, we predicted thatHomo sapiensmicroRNA-23b could recog-nize two sites in the 3¢-UTR of uPA and four sites in the c-met 3¢-UTR by the algorithm pictar. ...

17p viettel02 22-02-2013 45 3   Download

The tyrosine kinase expressed in hepatocellular carcinoma (Tec) is a non-receptor protein tyrosine kinase (PTK) that is expressed in hematopoietic cells, such as B and T lymphocytes, myeloid lineage cells and neutrophils. Mutations in the humanBtkgene cause X-linked agammaglobulinemia (XLA), but the corresponding mutation in mice results in a much milder defect.

11p viettel02 20-02-2013 33 3   Download

Because of the asymptomatic process of carcinogenesis, the early detection of cancers such as hepatocellular carcinoma (HCC) is very challenging. Tumor-prone transgenic mouse models of oncogenesis can provide a stable and powerful tool for the analysis of cancer initiation, and are therefore promising for the discovery of early putative biomarkers of HCC.

15p viettel02 19-02-2013 31 2   Download

MicroRNAs are an evolutionarily conserved class of endogenous noncod-ing RNAs that modulate gene expression at the post-transcriptional level. Recently, microRNA-23a (miR-23a) has been found to function as a growth-promoting and antiapoptotic factor in hepatocellular carcinoma cells.

9p viettel02 19-02-2013 25 2   Download

MicroRNAs are a class of small noncoding RNAs that function as key reg-ulators of gene expression at the post-transcriptional level. Recently, micr-oRNA-373 (miR-373) has been found to function as an oncogene in testicular germ cell tumors.

11p cosis54 05-01-2013 45 4   Download