Human disease

The loss of life in floods is due to both drowning and/or the spread of disease epidemics. The objectives of this study is to focus on estimating appropriate methods and functions for assessing the potential damages to human life in river basin due to floods.

3p vimaito 11-04-2025 1 1   Download

Clonorchiasis infection is a food-borne parasitic disease that significantly impacts on public health. Among the three species of small liver flukes, Clonorchis sinensis (C. sinensis) is the most prevalent. It is estimated that approximately 35 million individuals worldwide are infected with C. Sinensis, with those affected having a risk of developing cholangiocarcinoma. This study employed an analytical descriptive study, conducting cross-sectional surveys involving 459 individuals aged 18 and older at the study site.

6p tuongmotranh 18-03-2025 4 1   Download

Quantitative reverse transcription PCR (RT-qPCR) paired with stem-loop was utilized in this study to establish a process for detecting miRNA-425-5p in human plasma, contributing to accurate prognosis and early diagnosis of genetic diseases in humans, especially cancer diseases. Blood samples (n=12) collected from healthy volunteers in Ho Chi Minh City, were subjected to plasma extraction and then microRNA (miRNAs) isolation using the TRIzol method.

11p vihyuga 04-03-2025 6 1   Download

Currently, there are no studies providing data on normal thyroid anatomy images on ultrasound to document thyroid imaging for doctors in the country in general and in the Mekong River Delta in particular. Therefore, it is necessary to determine the size of a normal adult human thyroid gland by ultrasound and contribute to providing reference data for the training of clinicians, especially determining the dose of drugs to treat some thyroid diseases related to the size of the gland.

7p vinara 11-01-2025 3 1   Download

Genital warts are a disease with the highest proportion of sexually transmitted diseases, which are caused by Human Papillomaviruses. Currently, research on the impact on the quality of life of patients with genital warts in Vietnam is still very limited, while this is an issue that deserves attention and has been studied in many places around the world.

7p vinara 11-01-2025 2 1   Download

Nowadays, there are many factors causing the decrease of male reproductive function such as diet, routine, chemical, ... But some of them have not been paid appropriate attention to, especially the use of paracetamol, which has a significant negative effect on the reproductive process. In this study, we will summarize the results of several studies on the harmful effects of prolonged high-dose use of paracetamol on sperm number, quality, portability and testicular morphology in experimental animals and humans.

15p vinara 11-01-2025 6 1   Download

Helicobacter pylori is a bacterium associated with gastric diseases and disorders of the upper gastrointestinal tract. The gram-negative bacterium Helicobacter pylori is known as a persistent colonizer of the human stomach, and this bacteria is also involved in extra-intestinal diseases. In 1994, the International Agency for Research on Cancer, World Health Organization classified H. pylori as a class 1 carcinogen, the only bacterium given this classification.

11p vinara 11-01-2025 2 1   Download

Obesity is well known that in various human pathological states such as: essential hypertension, coronary heart disease, type 2 diabetes mellitus,... Insulin resistance plays an important role in pathological state of diabetes. Recently, Katz et al provided QUICKI index (Quantitative insulin sensitivity check index) for insulin resistance condition evaluation. We carried out this study to determine the prevalence of insulin resistance by the QUICKI index and to evaluate the correlation between QUICKI index and the fasting glucose, insulin concentration.

4p viuchiha 06-01-2025 3 1   Download

Group B streptococcus (GBS) infections are still the leading cause of invasive infections in neonates, specically they also seriously cause mortality and morbidity with underlying diseases in adults. Curently, there are ten GBS serotypes (Ia, Ib, and II-IX) and the resistance characteristic of GBS is important to clinical treatment.

5p viharuno 03-01-2025 5 2   Download

Unmanaged plastic waste will affect the environment and human health. The study was conducted to describe the current situation of plastic waste management and the health conditions related to plastic waste of people in Hai Duong commune, Central Vietnam, in 2020.

7p viharuno 03-01-2025 6 2   Download

Traditional CKD risk factors as well as HIV-related factors are major determinants of the prevalence of renal diseases among HIV patients. Few equations have been used in clinical practice for calculating creatinine clearance, however, the accuracy of these formulae in HIV patients has been different.

8p viharuno 03-01-2025 7 2   Download

Single-nucleotide polymorphisms (SNP) are common genetic changes in the human genome. In recent time, many scientists have shown their interests in studies on SNPs’ roles in the pathological risk especially in cancer and metabolic diseases.

27p tamynhan0 15-06-2020 23 1   Download

Researching this thesis with a view to: describe the knowledge, attitude and practice (KAP) of farmer exposure to pesticides; determine disease model and describe some factors related to farmer health in cultivating tea; construction and appreciate of effect of interfere model on human health protection suitably for current conditions in Thai Nguyen.

24p nguyenthiminh32 12-07-2014 136 5   Download

The human immunodeficiency virus type 1, HIV-1, genome encodes a highly conserved regulatory gene product, Vpr (96 amino acids), which is incorporated into virions in quantities equivalent to those of the viral Gag protein. In infected cells, Vpr is believed to function during the early stages of HIV-1 replication (such as transcription of the proviral genome and migration of preintegration nuclear complex), blocks cells in G2 phase and triggers apoptosis.

10p system191 01-06-2013 47 4   Download

Trypanosoma brucei is the cause of the diseases known as sleeping sickness in humans (T. brucei ssp. gambiense and ssp. rhodesiense) and ngana in domestic animals (T. brucei brucei) in Africa. Procyclic trypomastigotes, the tsetse vector stage, express a surface-bound trans-sialidase that transfers sialic acid to the glycosylphosphatidylinositol anchor of procyclin, a surface glycoprotein covering the parasite surface. Trans-sialidase is a unique enzyme expressed by a few trypanosomatids that allows them to scavenge sialic acid from sialylated compounds present in the infected host. ...

10p system191 01-06-2013 49 4   Download

Mitochondrial functional and structural impairment and generation of oxidative stress have been implicated in aging, various diseases and chemotherapies. This study analyzed azidothymidine (AZT)-caused failures in mitochondrial functions, in redox regulation and activation of the HIV-1 gene expression. We monitored intracellular concentrations of ATP and glutathione (GSH) as the indicators of energy production and redox conditions, respectively, during the time-course experiments with U937 and MOLT4 human lymphoid cells in the presence of AZT (0.05 mgÆmL)1) or H2O2 (0.01 mM) for 15–25 days.

7p system191 01-06-2013 46 3   Download

Mice expressing a C-terminal fragment of the prion protein instead of wild-type prion protein die from massive neuronal degeneration within weeks of birth. The C-terminal region of PrPc (PrP121–231) expressed in these mice has an intrinsic neurotoxicity to cultured neurones. Unlike PrPSc, which is not neurotoxic to neurones lacking PrPc expression, PrP121–231 was more neurotoxic to PrPc-deficient cells. Human mutations E200K and F198S were found to enhance toxicity of PrP121–231 to PrP-knockout neurones and E200K enhanced toxicity to wild-type neurones.

10p system191 01-06-2013 33 4   Download

Eukaryotic ribonuclease (RNase) H2 consists of one catalytic and two accessory subunits. Several single mutations in any one of these subunits of human RNase H2 cause Aicardi–Goutie`res syndrome. To examine whether these mutations affect the complex stability and activity of RNase H2, three mutant proteins of His-tagged Saccharomyces cerevisiaeRNase H2 (Sc-RNase H2*) were constructed. Sc-G42S*, Sc-L52R*, and Sc-K46W* contain single mutations in Sc-Rnh2Ap*, Sc-Rnh2Bp*, and Sc-Rnh2Cp*, respectively....

14p research12 29-04-2013 44 2   Download

ZntA, a bacterial zinc-transporting P-type ATPase, is homologous to two human ATPases mutated in Menkes and Wilson diseases. To explore the roles of the bacterial ATPase residues homologous to those involved in the humandiseases, we have introduced several pointmutations into ZntA. The mutants P401L, D628A and P634L corres-pond to the Wilson disease mutations P992L, D1267A and P1273L, respectively.

8p research12 29-04-2013 45 3   Download

Here we show, for the ®rst time, thein vitro formation of ®lamentous aggregates of phosphorylated tau protein in SH-SY5Y human neuroblastoma cells. The formation of suchaberrant aggregates, similar to thoseoccurringinvivoin Alzheimer's disease and other tauopathies, requires okadaic acid, a phosphatase inhibitor, to increase the level of phos-phorylated tau, and hydroxynonenal, a product of oxidative stress that selectively adducts and modi®es phosphorylated tau.

6p research12 29-04-2013 34 2   Download