Individual medicine

To determine the prevalence of MH and its correlation with cardiovascular risk factors and target organ damage in patients at C Hospital, Da Nang. Methods: This study involved 120 participants aged 40 to 70 years who visited C Hospital, Da Nang, between April 2021 and September 2022. The participants were divided into two groups: 60 individuals with cardiovascular risk factors and 60 individuals diagnosed with hypertension.

7p vihizuzen 26-05-2025 4 1   Download

Mental health literacy (MHL) remains insufficiently addressed in Vietnam, especially among individuals with chronic diseases, who face increased vulnerability to mental health problems. This study examines MHL levels among patients with chronic physical diseases and explores the associated sociodemographic factors, aiming to inform targeted interventions for enhanced mental health care.

8p vijiraiya 19-05-2025 1 1   Download

Metabolic-Associated Fatty Liver Disease (MAFLD) is affecting approximately 24% of individuals and potentially leading to cirrhosis and hepatocellular carcinoma. This study aims to assess the prevalence of MAFLD in chronic obstructive pulmonary disease (COPD) patients and analyze their clinical characteristics.

8p vijiraiya 19-05-2025 1 1   Download

Cerebral infarction can lead to severe consequences. According to traditional medicine theory, electro-acupuncture and ear acupuncture are some of the successful treatments for rehabilitating the motor functions of paralyzed limbs. The goal of this study is to evaluate the efficacy of combining ear acupuncture (AT4) with traditional electro-acupuncture to aid in the recovery of individuals experiencing limb paralysis due to a brain infarction.

7p vijiraiya 19-05-2025 1 1   Download

To evaluate the diagnostic value of PTGER4 (Prostaglandin E Receptor 4) gene methylation in plasma for lung cancer detection compared to healthy controls. Methods: A cross-sectional, case-control study was conducted on 149 non-small cell lung cancer (NSCLC) patients and 100 healthy individuals. Peripheral blood samples were collected for PTGER4 methylation analysis using real-time methylation-specific PCR (MSP).

8p vimitsuki 06-05-2025 1 1   Download

OECD guidelines were applied. Mice were divided into 7 groups consisting of 30 females and 10 males each. In which, the control group received the solvent, only females or males in 4 other groups were taken the testing samples (32), and both females and males of 2 remain groups were given those samples. Mice were given oral samples at a dose of 288 or 576 mg/kg/day × 7 consecutive days depending on individual group.

7p viinuzuka 28-02-2025 3 1   Download

Anthropometry is a part of physical anthropology, a science that allows the study of measurement methods on the human body and the use of mathematics to analyze the measured results in order to find patterns about human physical development. Measurement of the human body is one of the methods of assessing the general health and nutritional status of an individual or a population.

8p viakimichi 17-01-2025 5 2   Download

Today, the global challenge of malnutrition encompasses both undernutrition and overweight, particularly prevalent in low and middle-income nations. Excessive body fat accumulation poses health risks for overweight and obese individuals. Objectives: To assess nutritional status and identify related factors among Can Tho University of Medicine and Pharmacy (CTUMP) medical students.

7p vinara 11-01-2025 3 1   Download

The term “Entrepreneurship” refers to innovative, high-risk, and rapidly expanding business ventures that frequently need a substantial cash source. Most of the initial funding comes from individual savings or family’s financial support. The process of becoming an entrepreneur starts with identifying an opportunity and ends with creating a plan to take advantage of it.

9p vinara 11-01-2025 4 1   Download

Depression is a prevalent condition that affects individuals globally. It can cause significant emotional pain and hinder one's ability to perform well in various settings such as work, school, and home. Diagnosing and treating depression can be challenging due to limited resources, a shortage of trained healthcare providers, and the socialstigma often attached to mental disorders.

6p vinara 11-01-2025 1 1   Download

Cervical tooth wear is a common oral health issue that often leads to the loss of tooth structure integrity, making the teeth sensitive, prone to plaque buildup, affecting the dental pulp, and causing aesthetic concerns. To determine the prevalence and severity of cervical tooth wear in young individuals aged 18-25 and examine the association between brushing habits and cervical tooth wear.

6p viharuno 03-01-2025 3 2   Download

Research objective: Establish the genetic variants database of 04 genes CYP2C9, CYP2C19, CYP2D6 and CYP3A5 in Kinh Vietnamese. Identification of genotype and allele frequencies of 04 genes CYP2C9, CYP2C19, CYP2D6 and CYP3A5 in Kinh Vietnamese. Perform in silico functional analysis of novel variants.

27p extraenglish 24-05-2021 31 4   Download

Precision medicine promises to improve both the efficacy and safety of therapeutic products by better informing why some patients respond well to a drug, and some experience adverse reactions, while others do not. Pharmacogenomics is a key component of precision medicine and can be utilized to select optimal doses for patients, more precisely identify individuals who will respond to a treatment and avoid serious drug-related toxicities.

5p caothientrangnguyen 09-05-2020 16 2   Download

To establish stable cell lines that produce recombinant multisubunit proteins, it is usually necessary to cotransfect cells with several independent gene constructs. Here, we show that a stepwise fusion of individually transfected cells, results in a fused cell-line that secretes a complete multisubunit protein. Functional expression of recombinant multisubunit proteins may require a defined expression ratio between each protein subunit. The cell-fusion technology described allows a predefined expression level of each subunit.

6p system191 01-06-2013 41 4   Download

By replacing specific amino acids at positions 112, 147 and 152 of the human aldosterone synthase (CYP11B2) with the corresponding residues from human, mouse or rat 11b-hydroxylase (CYP11B1), we have been able to investigate whether these residues belong to structural determinants of individual enzymatic activities. When incubated with 11-deoxycorticosterone (DOC), the 11b-hydroxylation activity of the mutants was most effectively increased by combining D147E and I112P (sixfold increase).

10p research12 01-06-2013 39 5   Download

When theaand bchains were separated from human oxyhemoglobin (HbO2), each individual chain was oxidized easily to the ferric form, their rates being almost the same with a very strong acid-catalysis. In the HbO2tetramer, on theother hand, bothchains become considerably resistant to autoxidation over a wide range of pH values (pH 5±11).

10p research12 29-04-2013 43 4   Download

Eur. J. Biochem. 269, 5950–5955 (2002) Ó FEBS 2002 doi:10.1046/j.1432-1033.2002.03323.x The most active factor VIIa (FVIIa) variants identified to date carry concurrent substitutions at positions 158, 296and 298 with the intention of generating a thrombin-mimicking motif, optionally combined with additional replacements within the protease domain [Persson, E., Kjalke, M. & Olsen, O. H. (2001)Proc. Natl Acad. Sci. USA98, 13583– 13588]. Here we have characterized variants of FVIIa mutatedat one or twoof these positions toassess the relative importance of the individual replacements.

6p tumor12 22-04-2013 37 2   Download

The aimof this workwas to elucidate the roles of individual residues within the flexible second binding loop of human cystatin A in the inhibition of cysteine proteases. Four recombinant variants of the inhibitor, each with a single mutation, L73G, P74G, Q76G or N77G, in the most exposed part of this loopwere generated by PCR-based site-directed mutagenesis. The binding of these variants to papain, cathepsin L, and cathepsin B was characterized by equilibrium and kinetic methods.

10p tumor12 22-04-2013 35 2   Download

Opacity-associated (Opa) proteins are outer membrane proteins which play a critical role in the adhesion of patho-genicNeisseriaspp. to epithelial and endothelial cells and polymorphonuclear neutrophils. The adherence is mainly mediated by the CD66-epitope-containing members of the carcinoembryonic-antigen family of human cell-adhesion molecules (CEACAM). For the analysis of the specific in-teractions of individual Opa proteins with their receptors, pure protein is needed in its native conformation. ...

9p tumor12 22-04-2013 36 2   Download

Reconstitution of membrane proteins allows their study in a membrane environment that can be manipulated at will. Because membrane proteins have diverse biophysical pro-perties, reconstitution methods have so far been developed for individual proteins on an ad hoc basis. We developed a postinsertion reconstitution method for CCR5, a G protein coupled receptor, with seven transmembraneahelices and small ecto- and endodomains.

12p tumor12 22-04-2013 46 2   Download