Liver function

To investigate liver enzyme changes and assess liver function in patients with differentiated thyroid cancer who have undergone surgery and are preparing for radioiodine therapy (131I therapy). Methods: A cross-sectional descriptive study on 163 patients with differentiated thyroid cancer 4 - 6 weeks after surgery at the Military Institute of Radiation Medicine and Oncology from April 2023 to April 2024.

8p vimitsuki 06-05-2025 2 1   Download

Dengue hemorrhagic fever (DHF) is one of the most important diseases mosquitoes transmit due to its rapid spread and economic burden. This study aimed to assess the changes in serum aminotransferase levels (aspartate aminotransferase - AST and alanine aminotransferase - ALT) in DHF patients with or without warning signs and related factors.

10p vimitsuki 30-03-2025 1 1   Download

Topical medications derived from traditional medicines play a crucial role in dermatological treatment, often serving as the primary therapeutic approach. The underlying causes of dermatological conditions may include external factors such as wind, cold, dampness, heat, parasites, or internal imbalances such as stagnation of qi, blood stasis or deficiencies in liver and kidney function. Treatment methods in traditional medicine may incorporate remedies, surgical interventions, or a combination of both.

6p tuongmotranh 18-03-2025 4 1   Download

Human tissues such as liver, small intestine, spleen and kidney contain a cytosolic b-glucosidase (CBG) that hydrolyses variousb-D-glycosides, but whose physiological function is not known. Here, we describe the ®rst hetero-logous expression of human CBG, a system that facili-tated a detailed assessment of the enzyme speci®city towards dietary glycosides.

10p research12 29-04-2013 48 3   Download

A Drosophila melanogaster cDNA clone (GH01916) encoding a putative 723-residue long (82 kDa) protein (CG 7415) and displaying 50% identity with mammalian cytosolic dipeptidyl aminopeptidase (DPP) III was func-tionally expressed in Schneider S2 cells. Immunocytochemi-cal studies using anti-(rat liver DPP III) Ig indicated the expression of this putative DPP III at the outer cell mem-brane and into the cytosol of transfected cells.

9p tumor12 20-04-2013 37 3   Download

The relevance of functional amino acids for taurocholate transport by the sodium-dependent taurocholate cotrans-porting polypeptide Ntcp was determined by site-directed mutagenesis. cRNAfrom28 single-pointsmutants of the rat liver Ntcp clone was expressed in Xenopus laevisoocytes.

11p tumor12 20-04-2013 49 5   Download

Induction of CYP3A genes by the ligand-activated preg-nane-X-receptor (PXR)involves the interaction of other as yet unidentified liver transcription factors. Here we show that the CYP3A1promoter contains two active sites con-trolled by the CCAAT/enhancer-binding protein a (C/ EBPa), previously shown to regulate a number of liver stress response genes. We have identified two functional C/EBP binding sites at theCYP3A1promoter that confer luciferase activity to C/EBPacotransfected CHO cells.

9p tumor12 20-04-2013 46 4   Download

Aging is accompanied by a gradual deterioration of cell functions. Mitochondrial dysfunction and accumulation of protein damage have been proposed to contribute to this process. The present study was carried out to examine the effects of aging in mitochondrial matrix isolated from rat liver. The activity of Lon protease, an enzyme implicated in the degradation of abnormal matrix proteins, was meas-ured and the accumulation of oxidation and glycoxidation (N e -carboxymethyllysine, CML) products was monitored using immunochemical assays....

8p fptmusic 16-04-2013 31 2   Download

Previous work from this laboratory has shown that the spectral and functional properties of a prokaryotic xanthine dehydrogenase fromComamonas acidovoransshow some similarities to those of the well-characterized eukaryotic enzymes isolated from bovine milk and from chicken liver [Xiang, Q. & Edmondson, D.E. (1996) Biochemistry35, 5441–5450]. Therefore, this system was chosen to study the factors involved in the expression of functional recombinant enzyme in Escherichia colito provide insights into the assembly of the functional Mo-pyranopterin center....

11p fptmusic 12-04-2013 40 2   Download

HIP/PAP is a C-type lectin overexpressed in hepatocel-lular carcinoma (HCC). Pleiotropic biological activities have been ascribed to this protein, but little is known about the function of HIP/PAP in the liver. In this study, therefore, we searched for proteins interacting with HIP/PAP by screening a HCC cDNA expression library. We have identified the RIIa regulatory subunit of cAMP-dependent protein kinase (PKA) as a partner of HIP/PAP. HIP/PAP and RIIa were coimmunoprecipi-tated in HIP/PAP expressing cells. ...

9p awards 05-04-2013 32 4   Download

Mitochondrialb-oxidation is a complex pathway involving, in the case of saturated straight chain fatty acids of even carbonnumber, at least 16proteinswhichare organized into two functional subdomains; one associated with the inner face of the inner mitochondrial membrane and the other in the matrix. Overall, the pathway is subject to intramito-chondrial control at multiple sites. However, at least in the liver, carnitine palmitoyl transferase I exerts approximately 80% of control over pathway flux under normal conditions....

8p dell39 03-04-2013 41 2   Download

Peroxisome proliferator-activated receptora(PPARa) is thought to play an important role in lipid metabolism in the liver. To clarify the extra-hepatic and⁄or unknown function of PPARa, we previously performed a proteome analysis of the intestinal proteins and identified 17b-hydroxyster-

9p dell39 27-03-2013 36 3   Download

Chronic hepatitis C virus (HCV) infection is a clinically important liver disease with limited therapeutic options in a significant proportion of patients. Therefore, novel efficient therapeutic agents are needed. Because the 5¢- and 3¢-untranslated regions (UTRs) of HCV are highly conserved and functionally important for HCV replication, they are attractive targets for RNA-cleaving ribozymes or small interfering RNAs (siRNAs).

13p dell39 27-03-2013 52 5   Download

Injury of liver by ischaemia crucially involves mitochondrial damage. The role of Ca 2+ in mitochondrial damage is still unclear. We investigated the effect of low micromolar Ca 2+ concentrations on respiration, membrane permeability, and antioxidative defence in liver mitochondria exposed to hypoxia⁄reoxygenation. Hypoxia⁄reoxygenation caused decrease in state 3 respiration and in the respiratory control ratio.

9p dell39 27-03-2013 44 3   Download

Two histone H4 mRNA variants, H4-v.1 and histogranin mRNAs, were detected in the rat genome and measured in various tissues and isolated alveolar macrophages. Medium to high levels of both mRNAs were present in the liver, adrenal glands, thymus, bone marrow and alveolar macrophag-es. H4-v.1 cDNA contained an open reading frame that coded for unmodi-fied whole histone H4, whereas histogranin cDNA lacked the first ATG codon and contained an open reading frame that coded for modified (Thr89) H4-(84–102). ...

14p inspiron33 25-03-2013 57 5   Download

Hydrogen sulfide is a potent toxin of aerobic respiration, but also has physiological functions as a signalling molecule and as a substrate for ATP production. A mitochondrial pathway catalyzing sulfide oxidation to thio-sulfate in three consecutive reactions has been identified in rat liver as well as in the body-wall tissue of the lugworm,Arenicola marina.

10p galaxyss3 07-03-2013 41 4   Download

Aging is accompanied by gradual cellular dysfunction associated with an accumulation of damaged proteins, particularly via oxidative processes. This cellular dysfunction has been attributed, at least in part, to impair-ment of mitochondrial function as this organelle is both a major source of oxidants and a target for their damaging effects, which can result in a reduction of energy production, thereby compromising cell function.

13p media19 05-03-2013 52 3   Download

Impaired mitochondrial function contributes to copper- and cadmium-induced cellular dysfunction. In this study, we used modular kinetic analy-sis and metabolic control analysis to assess how Cd 2+ and Cu 2+ ions affect the kinetics and control of oxidative phosphorylation in isolated rat liver mitochondria.

13p vinaphone15 25-02-2013 57 2   Download

Bile acid-binding proteins (BABPs) are cytosolic lipid chaperones that play central roles in driving bile flow, as well as in the adaptation to various pathological conditions, contributing to the maintenance of bile acid homeostasis and functional distribution within the cell.

13p viettel02 20-02-2013 36 3   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Lanthanum associated abnormal liver function tests in two patients on dialysis: a case report

4p thulanh28 16-12-2011 55 5   Download