Medical consequences

To determine prevalence of hypothermia in elderly patients undergoing hip arthroplasty Methods: A prospective, cross-sectional descriptive study was conducted. Tympanic thermometers were used to measure body temperature in patients aged 60 years and older who underwent hip arthroplasty under general endotracheal anesthesia at the Department of Anesthesiology, Cho Ray Hospital, from December 2022 to December 2023.

6p vijiraiya 26-04-2025 1 1   Download

Mitochondrial uncoupling protein 1 (UCP1) is a speci®c marker of multilocular brown adipocytes. Ectopic UCP1 in white fat of aP2-Ucp1micemitigates development of obesity byboth, increasing energy expenditure anddecreasingin situ lipogenesis. In order to further analyse consequences of respiratory uncoupling inwhite fat, the e€ects of the ectopic UCP1 on the morphology of adipocytes and biogenesis of mitochondria in these cells were studied.

10p research12 29-04-2013 45 4   Download

Hu-K4 is a human protein homologous to the K4L protein of vaccinia virus. Due to the presence of two HKD motifs, Hu-K4 was assigned to the family of Phospholipase D proteins although so far no catalytic activity has been shown. The Hu-K4 mRNA is found in many human organs with highest expression levels in the central nervous system. We extended the ORF of Hu-K4 to the 5¢ direction. As a consequence the protein is 53 amino acids larger than originally predicted, now harbouring a putative transmembrane domain....

0p awards 06-04-2013 39 3   Download

Interaction of cytokines with their cognate receptors leads to the activation of latent transcription factors, the signal transducer and activator of transcription (STAT) proteins. Numerous studies have identified the critical roles played by STAT proteins in regulating cell proliferation, differ-entiation and survival. Consequently, the activity of STAT proteins is negatively regulated by a variety of different mechanisms, which include alternative splicing, covalent modifications, protein–protein interactions with negative regulatory proteins and proteolytic processing by pro-teases....

8p awards 05-04-2013 39 4   Download

The transcription factor nuclear factorjB(NF-jB) is an activator of multiple cytokines, chemokines and adhesion molecules, which are important in inflammatory diseases such as asthma, and is consequently considered as an attractive therapeutic target. In the present study, a con-stitutively active dominant version of IjBa,IjBaDN, was introduced into A549 pulmonary cells by adenovirus-mediated delivery. The dominant IjB, but not a null viral vector, prevented the induction of NF-jB-dependent transcription by both tumor necrosis factora(TNFa)and interleukin-1b(IL-1b). ...

7p dell39 03-04-2013 37 4   Download

The newly emerging field of systems biology involves a judicious interplay between high-throughput ‘wet’ experimentation, computational modelling and technology development, coupled to the world of ideas and theory. This interplay involves iterative cycles, such that systems biology is not at all confined to hypothesis-dependent studies, with intelligent, principled, hypothesis-generating studies being of high importance and consequently very far from aimless fishing expeditions.

22p inspiron33 26-03-2013 44 5   Download

Bacterial CMP kinases are specific for CMP and dCMP, whereas the rela-ted eukaryotic NMP kinase phosphorylates CMP and UMP with similar efficiency. To explain these differences in structural terms, we investigated the contribution of four key amino acids interacting with the pyrimidine ring of CMP (Ser36, Asp132, Arg110 and Arg188) to the stability, catalysis and substrate specificity ofEscherichia coliCMP kinase.

11p galaxyss3 19-03-2013 41 3   Download

Bone morphogenetic protein (BMP) signals play key roles throughout embryology, from the earliest patterning events, via tissue specification, through organ development and again in germ cell differentiation. While both input and the transducer molecules are rather well studied, the final outcome of a BMP signal is basically unpredictable and differs enormously between previously studied cell types.

9p galaxyss3 19-03-2013 67 4   Download

Friedreich’s ataxia results from a deficiency in the mitochondrial protein frataxin, which carries single point mutations in some patients. In the pres-ent study, we analysed the consequences of different disease-related muta-tions in vitro on the stability and dynamics of human frataxin.

11p galaxyss3 07-03-2013 43 4   Download

Hemoglobin is the most prominent protein in blood, transporting O2 and facilitating reactive oxygen and nitrogen species detoxification. Hemoglobin metabolism leads to the release of extra-erythrocytic hemoglobin, with potentially severe consequences for health. Extra-erythrocytic hemoglobin is complexed to haptoglobin for clearance by tissue macrophages.

9p vinaphone15 28-02-2013 41 2   Download

In anautogenous mosquitoes, egg development requires blood feeding and as a consequence mosquitoes act as vectors of numerous devastating dis-eases of humans and domestic animals. Understanding the molecular mechanisms regulating mosquito egg development may contribute signi-ficantly to the development of novel vector-control strategies.

12p vinaphone15 27-02-2013 38 2   Download

Ephrin receptor tyrosine kinase A3 (EphA3, EC 2.7.10.1) is a member of a unique branch of the kinome in which downstream signaling occurs in both ligand- and receptor-expressing cells. Consequently, the ephrins and ephrin receptor tyrosine kinases often mediate processes involving cell–cell con-tact, including cellular adhesion or repulsion, developmental remodeling and neuronal mapping.

10p vinaphone15 25-02-2013 38 3   Download

Autoantibodies against autologus tumor-associated antigens have been detected in the asymptomatic stage of cancer and can thus serve as biomar-kers for early cancer diagnosis. Moreover, because autoantibodies are found in sera, they can be screened easily using a noninvasive approach. Consequently, many studies have been initiated to identify novel autoanti-bodies relevant to various cancer types.

25p viettel02 20-02-2013 31 4   Download

Genomic stability is constantly threatened by DNA damage, caused by numerous environmental and intrinsic sources, including radiation, chemi-cals and oncogene expression. Consequently, cells have evolved a sophisti-cated signal transduction network to sense DNA damage and to mount an appropriate DNA damage response.

10p viettel02 20-02-2013 33 2   Download

Calcium is an extraordinarily versatile signaling ion, encoding cellular responses to a wide variety of external stimuli. In neurons, mitochondria can accumulate enormous amounts of calcium, with the consequence that mitochondrial calcium uptake, sequestration and release play pivotal roles in orchestrating calcium-dependent responses as diverse as gene transcrip-tion and cell death.

15p viettel02 19-02-2013 39 4   Download

Elevated cell death in human preimplantation embryos is one of the cellu-lar events compromising pregnancy rates after assisted reproductive tech-nology treatments. We therefore explored the molecular pathways regulating cell death at the blastocyst stage in human embryos cultured in vitro. Owing to limited availability of human embryos, these pathways were further characterized in mouse blastocysts.

15p mobifone23 18-01-2013 28 4   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Prevalence and consequences of patient safety incidents in general practice in the Netherlands: a retrospective medical record review study

7p toshiba22 22-11-2011 55 4   Download

Abstract X-ray crystal structure determination of agglutinin from abrus precatorius in Taiwan is presented. The crystal structure of agglutinin, a type II ribosome-inactivating protein (RIP) from the seeds of Abrus precatorius in Taiwan, has been determined from a novel crystalline form by the molecular replacement method using the coordinates of abrin-a as the template. The structure has space group P41212 with Z = 8, and been refined at 2.6 Å to R-factor of 20.4%. The rootmean-square deviations of bond lengths and angles from the standard values are 0.009 Å and 1.3°.

13p toshiba23 18-11-2011 60 5   Download

The highly pathogenic H5N1 is a major avian pathogen that crosses species barriers and seriously affects humans as well as some mammals. It mutates in an intensified manner and is considered a potential candidate for the possible next pandemic with all the catastrophic consequences. Methods: Nasal swabs were collected from donkeys suffered from respiratory distress. The virus was isolated from the pooled nasal swabs in specific pathogen free embryonated chicken eggs (SPF-ECE).

6p toshiba23 18-11-2011 57 5   Download

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Natural History and Clinical Consequences of Hepatitis B Virus Infection...

5p thulanh9 07-10-2011 67 4   Download