Mitochondrial genome

Research purpose: Determine the composition, structure of mitochondrial genome, compare the difference in sequence, identify specific genetic characteristics of the six indigenous pig breeds, thereby contributing to the database to identification and conservation.

27p extraenglish 24-05-2021 29 4   Download

Collecting complete data of mitochondrial genome of 6 indigenous pig breeds in Vietnam (I, Mong Cai, Muong Lay, Huong, Muong Khuong and Ha Lang pigs) and deposited on the Genebank; determine the composition, structure of mitochondrial genome, compare the difference in sequence, identify specific genetic characteristics of the six indigenous pig breeds, thereby contributing to the database to identification and conservation.

27p capheviahe26 25-01-2021 16 4   Download

Most (78%) mitochondrial genomes in the studied mutant strain of Drosophila subobscura have undergone a large-scale deletion (5 kb) in the coding region. This mutation is stable, and is transmitted intact to the offspring. This animal model of major rearrangements of mitochondrial genomes can be used to analyse the involvement of the nuclear genome in the production and maintenance of these rearrangements.

8p research12 01-06-2013 52 6   Download

Despite the likely requirement for a DNA topoisomerase II activity during synthesis of mitochondrial DNA in mam-mals, this activity has been very difficult to identify convin-cingly.TheonlyDNAtopoisomerase II activity conclusively demonstrated to be mitochondrial in origin is that of a type II activity found associated with the mitochondrial, kineto-plast DNAnetwork in trypanosomatid protozoa [Melendy, T., Sheline, C., and Ray, D.S. (1988)Cell55, 1083–1088; Shapiro, T.A.,Klein,V.A., andEnglund, P.A. (1989)J.Biol. Chem.264, 4173–4178]....

14p tumor12 20-04-2013 28 3   Download

Termination of mitochondrial (mt) H-strand transcription in mammalian cells occurs at two distinct sites on the genome. The first site of termination, referred to as mt-TERM occurs beyond the 16 S rRNA gene. However, the second and final site of termination beyond the tRNA Thr gene remains unclear. In this study we have characterized the site of termination of the polycistronic distal gene transcript beyond the D-loop region, immedi-ately upstream of the tRNA Phe gene.

13p tumor12 20-04-2013 48 3   Download

The effects of physiologically relevant hypoxia on the catalytic activity of cytochromecoxidase (CytOX), mito-chondrial gene expression, and both nuclear and mito-chondrial encoded CytOX mRNA levels were investigated in murine monocyte macrophages, mouse C2C12 skeletal myocytes and rat adrenal pheochromocytoma PC12 cells. Our results suggest a coordinated down regulation of mito-chondrial genome-coded CytOX I and II and nuclear genome-codedCytOX IV andVbmRNAs during hypoxia.

9p tumor12 20-04-2013 35 3   Download

Eukaryotic genomes are composed of isochores, i.e. long sequences relat-ively homogeneous in GC content. In this paper, the isochore structure of Arabidopsis thalianagenome has been studied using a windowless technique based on theZcurve method and intuitive curves are drawn for all the five chromosomes. Using these curves, we can calculate the GC content at any resolution, even at the base level.

9p fptmusic 11-04-2013 44 3   Download

Mitochondrial biogenesis is a complex and highly regulated process that requires the controlled expression of hundreds of genes encoded in two separated genomes, namely the nuclear and mitochondrial genomes. To identify regulatory proteins involved in the transcriptional control of key nuc-lear-encoded mitochondrial genes, we have performed a detailed analysis of the promoter region of theasubunit of the Drosophila melanogasterF1F0 ATP synthase complex.

11p awards 05-04-2013 45 5   Download

The ESSS protein is a recently identified subunit of mam-malian mitochondrial complex I. It is a relatively small integral membrane protein (122 amino acids) found in the b-subcomplex. Genomic sequence database searches reveal its localization to theX-chromosome inhumans andmouse. TheESSScDNAfromChinesehamster cellswas clonedand shown to complement one complementation group of our previously described mutants with a proposed X-linkage. Sequence analyses of the ESSS cDNA in these mutants revealed chain termination mutations. ...

9p awards 05-04-2013 38 5   Download

Peroxiredoxins belong to a family of antioxidant proteins that neutralize reactive oxygen species. One member of this family, peroxiredoxin I (PRDX1), suppresses DNA oxidation. Peroxiredoxin V (PRDX5) has been cloned as a transcriptional corepressor, as a peroxisomal⁄mitochondrial antioxidant protein, and as an inhibitor of p53-dependent apoptosis.

11p inspiron33 26-03-2013 53 4   Download

The finding of a genome-wide oscillation in transcription that gates cells into S phase and coordinates mitochondrial and metabolic functions has altered our understanding of how the cell cycle is timed and how stable cellular phenotypes are maintained.

13p media19 06-03-2013 42 4   Download

Complex IV is the terminal enzyme of the mitochondrial respiratory chain. In humans, biogenesis of complex IV involves the coordinated assembly of 13 subunits encoded by both mitochondrial and nuclear genomes. The early stages of complex IV assembly involving mitochondrial DNA-encoded subunits CO1 and CO2 have been well studied.

13p viettel02 20-02-2013 32 4   Download

The role of non-B DNA in the function and stability of genomes has become generally appreciated in recent years. It is now evident that DNA also encodes for spatial structures that are involved in gene regulation, replication and recombination.

12p viettel02 19-02-2013 39 3   Download

The mitochondrial carriers are a family of transport proteins that shuttle metabolites, nucleotides and cofactors across the inner mitochondrial mem-brane. The genome ofDrosophila melanogasterencodes at least 46 mem-bers of this family. Only five of these have been characterized, whereas the transport functions of the remainder cannot be assessed with certainty.

10p mobifone23 18-01-2013 35 4   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Génétique et évolution du génome mitochondrial des Métazoaires

25p toshiba21 16-11-2011 30 3   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Genome-wide deletion mutant analysis reveals genes required for respiratory growth, mitochondrial genome maintenance and mitochondrial protein synthesis in Saccharomyces cerevisiae...

0p thulanh21 15-11-2011 56 2   Download

Published: 12 March 2004 Genome Biology 2004, 5:318 The electronic version of this article is the complete one and can be found online at http://genomebiology.com/2004/5/4/318 © 2004 BioMed Central Ltd reports A report on the 2004 Keystone Symposium ‘Human Genome Sequence Variation and the Inherited Basis of Common Disease’, Breckenridge, USA, 8-13 January 2004. General Hospital, Boston, USA) described a genetic analysis of diabetes. He showed preliminary results suggesting that mitochondrial DNA is involved in type II diabetes and hypothesized that primary...

0p thulanh21 15-11-2011 46 3   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Phylogeny of the M superhaplogroup inferred from complete mitochondrial genome sequence of Indian specific lineages...

23p thulanh19 09-11-2011 45 3   Download