Model compound

Garlic has been utilized since ancient times for both culinary and medicinal purposes. Recent research has identified selenium compounds in garlic, including γ-Glutamyl-Se-methylselenocysteine (GGMSC), leading to the hypothesis that GGMSC acts as a carrier for Se-methylselenocysteine (MSC). Experiments conducted on animals by researchers indicate that the effects of GGMSC in garlic and MSC on cancer cells in experimental models are equivalent. This finding suggests that garlic is a potential chemotherapeutic agent to enhance cancer treatment.

5p tuongmotranh 18-03-2025 3 1   Download

Resveratrol is a naturally occurring compound with anti-inflammatory properties. However, the protective molecular mechanisms of resveratrol against LPS-induced inflammation have not been thoroughly known. In the present study, we examined the antiinflammatory effect of resveratrol in inflammatory model using murine macrophage-like cell RAW264.7 stimulated with LPS. Resveratrol suppressed the production of inflammatory cytokines in LPS-stimulated RAW264.7 cells with the IC50 value as 17.5 ± 0.7 μM for IL-6, 14.2 ± 1.9 μM for IL-10, and 18.9 ± 0.6 μM for TNF-α.

9p xuanphongdacy06 18-09-2024 1 1   Download

Master's thesis of Science "Investigation into the modulation of circadian clock proteins by dietary compounds and small molecules" is structured as follows: Chapter 1 Introduction; Chapter 2 Identification of novel bioactive compounds from Olea europaea by evaluation of chemical compounds in the OliveNetTM library: in silico bioactivity and molecular modelling, and in vitro validation of hERG activity; Chapter 3 Modulation of circadian core clock proteins by dietary compounds; Chapter 4 Molecular mechanisms of action of selected olive phenolics against epigenetic modifiers and the structur...

235p runthenight04 02-02-2023 8 3   Download

Building approximation formulas using equivalentinclusion method to determine the effective values of the conductivity, the elastic modulus of compound-inclusion composite materials and applying numerical methods using finite elements (FE) calculated for some specific material models.

27p capheviahe26 25-01-2021 23 4   Download

In this paper, we propose a three-phase multi-attribute ranking approach having as outcomes of the modeling phase what we refer to as net superiority and inferiority indexes. These are defined as bounded differences between the classical superiority and inferiority indexes.

12p tohitohi 22-05-2020 24 1   Download

A real inventory system for single item with specific demand characteristics motivates this works. The demand can be seen as two types of independent demand, where compound Poisson process describes the characteristics of each demand.

10p tohitohi 22-05-2020 22 1   Download

The aim of Caffeine and chlorogenic acid separation from raw coffee beans using supercritical CO2 in water was to develop new process for extracting and separating hydrophilic and hydrophobic compounds from coffee beans using supercritical CO in water. In this work, experiments and simulation of the process has been conducted. Chlorogenic acid and caffeine from coffee beans were used as model compounds of hydrophilic and hydrophobic compounds, respectively.

8p phannguyen05 16-03-2015 63 5   Download

Recovering useful hydrocarbons from sewage sludge using zirconia-supporting iron oxide catalysts was investigated. Zirconia has activity for decomposing water molecules to generate active oxygen and hydrogen species.

6p tuananhhumg 04-11-2013 38 3   Download

The invertebrate nuclear receptor, ultraspiracle (USP), an ortholog of the vertebrate RXR, is typically modelled as an orphan receptor that functions without a ligand-binding activity. The identification of a ligand that can transcrip-tionally activate USP would provide heuristic leads to the structure of potentially high affinity activating compounds, with which to detect unknown regulatory pathways in which this nuclear receptor participates.

11p tumor12 22-04-2013 41 2   Download

The sulfonephthalein indicator, phenol red, exhibits an unusually slow rate of oxidation by laccase fromPolipo-rus pinsitus, in spite of the fact that it is a phenol and therefore a natural substrate for this phenoloxidase enzyme. Nevertheless, after prolonged exposure to laccase (24 h) phenol red is oxidized by more than 90%.

7p tumor12 20-04-2013 42 2   Download

CYP73 enzymes are highly conserved cytochromes P450 in plant species that catalyse the regiospecific 4-hydroxylation ofcinnamicacid to formprecursorsofligninandmanyother phenolic compounds. A CYP73A1 homology model based on P450 experimentally solved structures was used to iden-tify active site residues likely togovern substrate binding and regio-specific catalysis. The functional significance of these residues was assessed using site-directedmutagenesis.

12p tumor12 20-04-2013 42 3   Download

Purified manganese peroxidase (MnP) fromPhanerocha-ete chrysosporiumoxidizes nonphenolicb-1 diarylpropane lignin model compounds in the presence of Tween 80,and in three- to fourfold lower yield in its absence. In thepresence of Tween 80,1-(3¢,4¢-diethoxyphenyl)-1-hydroxy-2-(4¢-methoxyphenyl)propane (I) was oxidized to 3,4-diethoxy-benzaldehyde (II),4-methoxyacetophenone (III) and 1-(3¢,4¢-diethoxyphenyl)-1-oxo-2-(4¢-methoxyphenyl)pro-pane (IV),while only 3,4-diethoxybenzaldehyde (II) and 4-methoxyacetophenone (III) were detected when the reac-tion was conducted in the absence of Tween 80..

9p tumor12 20-04-2013 43 4   Download

A 6A,6A¢-dicyclohexylamine-6B,6B¢-diselenide-bis-b-cyclodextrin (6-CySeCD) was designed and synthesized to imitate the antioxidant enzyme glutathione peroxidase (GPX). In this novel GPX model,b-cyclodextrin provided a hydrophobic environment for substrate binding within its cavity, and a cyclohexylamine group was incorporated into cyclodextrin in proximity to the catalytic selenium in order to increase the stability of the nucleophilic intermediate selenolate.

9p galaxyss3 21-03-2013 52 4   Download

EURASIP Journal on Applied Signal Processing 2003:12, 1181–1187 c 2003 Hindawi Publishing Corporation A Fast and Efficient Topological Coding Algorithm for Compound Images Xin Li Lane Department of Computer Science and Electrical Engineering, West Virginia University, Morgantown, WV 26506, USA Email: xinl@csee.wvu.edu Received 11 September 2002 and in revised form 8 June 2003 We present a fast and efficient coding algorithm for compound images.

7p sting12 10-03-2012 49 7   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Pharmacological characterisation of antiinflammatory compounds in acute and chronic mouse models of cigarette smoke-induced inflammation...

10p toshiba11 19-10-2011 60 3   Download