Nervous system
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The aims of the study "Characterising microbial and neuroimmune interactions in a mouse model of autism" are threefold: i) To characterize the influence of the R451C mutation on caecal enteric neuron organization; ii) To characterize the influence of the R451C mutation on caecal patch macrophage density and morphology; iii) To assess for alterations in gut microbes in different regions of the GI tract in the NL3R451C mouse model of autism.
83p runthenight04 02-02-2023 7 1 Download
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"Master's thesis of Science: Intestinal permeability and functional properties of duodenal enteric neurons in a mouse model of autism" is structured as follows: Chapter 1: Introduction; Chapter 2: Measuring intestinal permeability in the Neuroligin-3R451C mouse model of autism; Chapter 3: Optimisation of the patch-clamp recording technique in the enteric nervous system to examine action potential characteristics in mouse duodenal myenteric neurons.
147p runthenight04 02-02-2023 10 3 Download
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Melanoma-intrinsic activated β-catenin pathway, the product of the catenin beta 1 (CTNNB1) gene, has been associated with low/absent tumor-infiltrating lymphocytes, accelerated tumor growth, metastases development, and resistance to anti-PD-L1/anti-CTLA-4 agents in mouse melanoma models.
14p vielonmusk 21-01-2022 9 0 Download
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High-dose methotrexate (HD-MTX) has broad use in the treatment of central nervous system (CNS) malignancies but confers significant toxicity without inpatient hydration and monitoring. Glucarpidase is a bacterial recombinant enzyme dosed at 50units (u)/kg, resulting in rapid systemic MTX clearance.
10p vielonmusk 21-01-2022 15 1 Download
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It is unknown whether and to what degree trials submitted to the US FDA to support drug approval adhere to NCCN guideline-recommended care in their baseline and surveillance CNS imaging protocols. Objective: We sought to characterize the frequency with which the trials cited in US FDA drug approvals for first line advanced NSCLC between 2015 and 2020 deviated from NCCN guideline-recommended care for baseline and surveillance CNS imaging.
8p vielonmusk 21-01-2022 12 0 Download
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Regulators of G protein signaling (RGS) proteins modulate G protein-coupled receptor (GPCR) signaling networks by terminating signals produced by active Gα subunits. RGS17, a member of the RZ subfamily of RGS proteins, is typically only expressed in appreciable amounts in the human central nervous system, but previous works have shown that RGS17 expression is selectively upregulated in a number of malignancies, including lung, breast, prostate, and hepatocellular carcinoma.
10p caothientrangnguyen 09-05-2020 11 0 Download
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Regulator of G protein signaling (RGS) proteins are gatekeepers regulating the cellular responses induced by G protein-coupled receptor (GPCR)-mediated activation of heterotrimeric G proteins. Specifically, RGS proteins determine the magnitude and duration of GPCR signaling by acting as a GTPase-activating protein for Gα subunits, an activity facilitated by their semiconserved RGS domain. The R7 subfamily of RGS proteins is distinguished by two unique domains, DEP/DHEX and GGL, which mediate membrane targeting and stability of these proteins.
13p caothientrangnguyen 09-05-2020 22 1 Download
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Regulator of G-protein signaling (RGS) proteins were originally identified as negative regulators of G-protein-coupled receptor (GPCR) signaling via their GTPase-accelerating protein (GAP) activity. All RGS proteins contain evolutionarily conserved RGS domain; however, they differ in their size and regulatory domains. RGS1 and RGS10 are smaller than other RGS proteins, and their functions involve various inflammatory responses including autoimmune responses in both the periphery and the central nervous system (CNS). Neuroinflammation is the chronic inflammatory response in the CNS.
5p caothientrangnguyen 09-05-2020 23 1 Download
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This chapter students will be able to: List the basic functions of the nervous system; explain the structural and functional divisions of the nervous system; list the types of neuroglia and cite their functions; define neuron, describe its important structural components, and relate each to a functional role;...
47p tangtuy07 02-04-2016 46 2 Download
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Chapter 11 - Fundamentals of the nervous system and nervous tissue (part b). In this chapter, you will learn: Define resting membrane potential and describe its electrochemical basis, compare and contrast graded potentials and action potentials, explain how action potentials are generated and propagated along neurons,...
55p tangtuy07 02-04-2016 41 2 Download
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In this chapter, students will be able to understand: Define synapse, distinguish between electrical and chemical synapses by structure and by the way they transmit information, distinguish between excitatory and inhibitory postsynaptic potentials, describe how synaptic events are integrated and modified,...
80p tangtuy07 02-04-2016 31 2 Download
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Chapter 12 - The central nervous system (part a), the topics discussed in this chapter are: Central Nervous System (CNS), embryonic development, effect of space restriction on brain development, regions and organization of the CNS, ventricles of the brain,...and other contents.
60p tangtuy07 02-04-2016 37 2 Download
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Chapter 12 - The central nervous system (part b), this chapter includes contents: Lateralization of cortical function, cerebral white matter, basal nuclei (ganglia), functions of basal nuclei, diencephalon, thalamus, thalamic function, hypothalamic function,...
45p tangtuy07 02-04-2016 42 2 Download
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Chapter 12 - The central nervous system (part c), in this chapter you will learn about the following: Functional brain systems, limbic system, limbic system: emotion and cognition, reticular formation, reticular formation: RAS and motor function, electroencephalogram (EEG), brain waves,...and other contents.
63p tangtuy07 02-04-2016 39 2 Download
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After completing this unit, you should be able to: Describe the embryonic development of the spinal cord; describe the gross and microscopic structure of the spinal cord; list the major spinal cord tracts, and classify each as a motor or sensory tract; distinguish between flaccid and spastic paralysis, and between paralysis and paresthesia;...
49p tangtuy07 02-04-2016 41 2 Download
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In this chapter, you will learn to: Define peripheral nervous system and list its components; classify general sensory receptors by structure, stimulus detected, and body location; outline the events that lead to sensation and perception; describe receptor and generator potentials and sensory adaptation; describe the main aspects of sensory perception.
40p tangtuy07 02-04-2016 56 2 Download
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The peripheral nervous system and reflex activity (part c) provides knowledge of spinal nerves. The goal is for you to learn: Describe the formation of a spinal nerve and the general distribution of its rami; define plexus, name the major plexuses and describe the distribution and function of the peripheral nerves arising from each plexus.
28p tangtuy07 02-04-2016 50 4 Download
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Chapter 13 - The peripheral nervous system and reflex activity (part b). This chapter define ganglion and indicate the general body location of ganglia, describe the general structure of a nerve, follow the process of nerve regeneration, name the 12 pairs of cranial nerves, indicate the body region and structures innervated by each.
30p tangtuy07 02-04-2016 49 3 Download
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Chapter 13 (part d) provides knowledge of motor endings and motor activity. In this chapter, students will be able to compare and contrast the motor endings of somatic and autonomic nerve fibers, outline the three levels of the motor hierarchy, compare the roles of the cerebellum and basal nuclei in controlling motor activity.
55p tangtuy07 02-04-2016 62 3 Download
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Chapter 14 provides knowledge of the autonomic nervous system. In this chapter, you will learn to: Define autonomic nervous system and explain its relationship to the peripheral nervous system; compare the somatic and autonomic nervous systems relative to effectors, efferent pathways, and neurotransmitters released; compare and contrast the functions of the parasympathetic and sympathetic divisions;...
60p tangtuy07 02-04-2016 46 2 Download