Ovarian cancer
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Ovarian cancer constitutes one of the most lethal gynecologic malignancies for females. Currently, early detection strategies and therapeutic options for ovarian cancer are far from satisfactory, leading to high diagnosis rates at late stages and disease relapses. New avenues of therapy are needed that target key processes in ovarian cancer progression.
20p vimichaelfaraday 25-03-2022 14 1 Download
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The aim of the thesis: Conducted with 2 objectives: Understanding the correlation between tumor markers CA125 and HE4 in ovarian cancer diagnosis; evaluation of the role of tumor markers CA125 and HE4 in monitoring and treating ovarian cancer. Mời các bạn cùng tham khảo nội dung chi tiết.
28p badbuddy07 26-02-2022 14 3 Download
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Patients with pathogenic sequence variants (PSVs) in BRCA1/BRCA2 are at high risk of developing ovarian cancer (OC). However, genetic testing for BRCA1/BRCA2 PSVs is still not a routine practice in the Middle East. With the lack of epidemiological studies in the region, we aim to describe the prevalence of BRCA1/BRCA2 PSVs in patients with OC across diferent countries in the Gulf region.
8p vielonmusk 21-01-2022 8 0 Download
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Circular RNAs (circRNAs) are more stable than linear RNA molecules, which makes them promising diagnostic biomarkers for diseases. By circRNA-sequencing analysis, we previously found that circN4BP2L2 was significantly decreased in epithelial ovarian cancer (EOC) tissues, and was predictive of disease progression.
15p vielonmusk 21-01-2022 21 0 Download
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BRCA gene mutations (BRCAm) have an impact on patients’ characteristics and clinical outcomes of ovarian cancer (OC). The frequency and patterns of BRCAm vary among countries and ethnicities. There are limited data from Saudi Arabia (SA); thus, this study aims to determine the frequency, pattern, and impact on patient characteristics and outcomes of BRCAm OC compared to wild-type BRCA (BRCAw) in Saudi women.
9p vielonmusk 21-01-2022 11 0 Download
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PHI-101 is an orally available, selective checkpoint kinase 2 (Chk2) inhibitor. PHI-101 has shown antitumour activity in ovarian cancer cell lines and impaired DNA repair pathways in preclinical experiments. Furthermore, the in vivo study suggests the synergistic effect of PHI-101 through combination with PARP inhibitors for ovarian cancer treatment.
7p vielonmusk 21-01-2022 18 1 Download
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Administration of poly (ADP-ribose) polymerase (PARP) inhibitors after achieving a response to platinum-containing drugs significantly prolonged relapse-free survival compared to placebo administration. PARP inhibitors have been used in clinical practice. However, patients with platinum-resistant relapsed ovarian cancer still have a poor prognosis and there is an unmet need.
11p vielonmusk 21-01-2022 8 0 Download
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Platinum-resistant cases account for 25% of ovarian cancer patients. Our aim was to construct two novel prognostic models based on gene expression data respectively from ferroptosis and necroptosis, for predicting the prognosis of advanced ovarian cancer patients with platinum treatment.
13p vielonmusk 21-01-2022 13 1 Download
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This study aims to evaluate the role of the fibrinogen/albumin ratio (FAR) in predicting platinum resistance and survival outcomes of patients with ovarian clear cell carcinoma (OCCC). Methods: Coagulation function and D-dimer, serum albumin, CA125 and HE4 levels were measured before surgery in OCCC patients undergoing initial surgery in our institution.
10p vielonmusk 21-01-2022 16 1 Download
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In this study, we developed a mAb against CA125 to be used as a capture antibody in ELISA technique for detecting CA125 concentration in sera of OC and BC patients. The results of CA125 level in this study were compared with that performed using a commercial CA125 ELISA kit.
8p nguaconbaynhay10 20-02-2021 9 2 Download
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Regulators of G protein signaling (RGS) proteins modulate G protein-coupled receptor (GPCR) signaling networks by terminating signals produced by active Gα subunits. RGS17, a member of the RZ subfamily of RGS proteins, is typically only expressed in appreciable amounts in the human central nervous system, but previous works have shown that RGS17 expression is selectively upregulated in a number of malignancies, including lung, breast, prostate, and hepatocellular carcinoma.
10p caothientrangnguyen 09-05-2020 11 0 Download
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NBR1(named as next toBRCA1) was originally cloned as a candidate gene for the ovarian cancer antigen CA125, using expression cloning with the anti-CA125 Ig, OC125.NBR1 has been of interest due to its position close toBRCA1, although no involvement in breast or ovarian cancer has been demonstrated. Recently, the antigen CA125 has been cloned, and identi®ed as a new mucin, MUC16, entirely dierent from NBR1.
8p research12 23-04-2013 42 2 Download
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In birds, the egg envelope surrounding the oocyte prior to ovulation is called the perivitelline membrane and it plays important roles in fertiliza-tion. In a previous study we demonstrated that one of the components of the perivitelline membrane, ZP3, which is secreted from the ovarian granu-losa cells, specifically interacts with ZP1, another constituent that is synthe-sized in the liver of Japanese quail.
10p galaxyss3 07-03-2013 44 3 Download
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The hypothalamic decapeptide gonadotropin-releasing hormone (GnRH) is well known for its role in the control of pituitary gonadotropin secretion, but the hormone and receptor are also expressed in extrapituitary tissues and tumor cells, including epithelial ovarian cancers.
16p vinaphone15 28-02-2013 30 3 Download
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MicroRNAs are emerging as important regulators of cancer-related pro-cesses. Our studies show that microRNA-9 (miR-9) is downregulated in human ovarian cancer relative to normal ovary, and overexpression of miR-9 suppresses cell growthin vitro. Furthermore, the 3¢-UTR of NF-jB1 mRNA is found to be regulated directly by miR-9, demonstrating that NF-jB1 is a functionally important target of miR-9 in ovarian cancer cells.
10p viettel02 20-02-2013 20 2 Download
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The standard chemotherapy for epithelial ovarian cancer (EOC) patients is currently a combination of taxane and platinum. However, most EOC patients still suffer relapses, and there is an immediate need for the devel-opment of novel and more effective therapeutic modalities against this deadly disease.
15p viettel02 19-02-2013 35 3 Download
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Mutations in the tumor suppressor breast cancer susceptibility gene 1 (BRCA1), an important player in the DNA damage response, apoptosis, cell cycle regulation and transcription, confer a significantly elevated life-time risk for breast and ovarian cancer.
11p viettel02 19-02-2013 49 2 Download
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The protein annexin IV (ANX4) is elevated specifically and characteristi-cally in ovarian clear cell adenocarcinoma (CCA), a highly malignant histo-logical subtype of epithelial ovarian cancer. On the basis of the hypothesis that the expression of ANX4in CCA is regulated by a unique transcription mechanism, we explored thecis-elements involved in CCA-specific ANX4 expression using a luciferase reporter.
14p cosis54 05-01-2013 35 4 Download
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Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Gene Expression and Pathway Analysis of Ovarian Cancer Cells Selected for Resistance to Cisplatin, Paclitaxel, or Doxorubicin
28p sting01 15-01-2012 60 6 Download
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Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Role of CA125 in predicting ovarian cancer survival - a review of the epidemiological literature
20p sting01 15-01-2012 40 4 Download