Oxidation Numbers
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Peroxisomes are pivotal metabolic organelles that exist in almost all eukaryote cells. A reduction in numbers and enzymatic activities of peroxisomes was found in colon adenocarcinomas. However, the role of peroxisomes or the peroxisome pathway in colorectal cancer (CRC) is not defined.
17p vielonmusk 21-01-2022 11 0 Download
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Regulator of G-protein signaling (RGS) proteins were originally identified as negative regulators of G-protein-coupled receptor (GPCR) signaling via their GTPase-accelerating protein (GAP) activity. All RGS proteins contain evolutionarily conserved RGS domain; however, they differ in their size and regulatory domains. RGS1 and RGS10 are smaller than other RGS proteins, and their functions involve various inflammatory responses including autoimmune responses in both the periphery and the central nervous system (CNS). Neuroinflammation is the chronic inflammatory response in the CNS.
5p caothientrangnguyen 09-05-2020 23 1 Download
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The measured Nusselt numbers showed a trend similar to those of existing studies, but the absolute values showed discrepancies owing to the high Prandtl number of this system. The measured angle-dependent Nusselt numbers were analyzed for 2-D and 3-D geometries, and a multiplier was developed that enables the extrapolation of 2-D data into 3-D data.
9p minhxaminhyeu4 26-06-2019 19 2 Download
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At the present, in order to increase octan number the izomerization of hydrocarbon has been studied in the world. Amongs metals and metal oxides on carriers, Pt on the alumina carrier is used most widely owing to the advantages such as thermal stability, high activity and high selectivity etc. The conversion and selectivity of the izomerization depend on the catalysts (the composition of the catalysts, the structure of the carriers, the distribution of metal, the acidity, the catalytic activity of the catalysts) and the reaction condition (temperature, volume flow, carrier gases ...).
4p uocvong04 24-09-2015 61 4 Download
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In this paper, nickel oxide thin films on the titanium substrate were prepared by the sol-gel dipcoating technique with the precursors NiSO4.7H2O and acetic acid. The obtained thin films have a good adhesion to the substrate. The electrochemical behaviors of the NiOxHy thin films were investigated in KOH 1 M solution by the voltammetry technique. The effect of addition of platinum, heating temperature and the dip coating number on the electrochemical behavior was also investigated. The thin films have high electrochemical properties at 270o C and at third dip coating.
5p uocvong03 24-09-2015 69 3 Download
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A central metal atom bonded to a group of molecules or ions is a metal complex. • If it’s charged, it’s a complex ion. Chemistry • Compounds containing complexes are coordination of Coordination Compounds compounds.The molecules or ions coordinating to the metal are the ligands.
77p tringuyen215dh11h1 05-10-2013 59 5 Download
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During the last decade several novel yeast genes encoding proteins related to the PPP family of Ser/Thr protein phosphatases have been discovered and their functional characterization initiated. Most of these novel phosphatases display intriguing structural features and/or are involved in a number of important functions, such as cell cycle regulation, protein synthesis and maintenance of cellular integrity. While in some cases these genes appear to be restricted to fungi, in others similar proteins can be found in higher eukaryotes. ...
6p research12 01-06-2013 26 2 Download
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The casein milk proteins and the brain proteinsa-synuclein and tau have been described as natively unfolded with ran-domcoil structures,which, inthecaseofa-synucleinandtau, have a propensity to form the ®brils found in a number of neurodegenerative diseases. New insight into the structures of these proteins has been provided by a Raman optical activity study, supplemented with dierential scanning cal-orimetry, of bovineb-andj-casein, recombinant humana-, b-andc-synuclein,
9p research12 29-04-2013 40 3 Download
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Pseudomonas aeruginosais an opportunistic Gram-negative bacterium that causes severe infections in a number of hosts from plants to mammals. A-band lipopolysaccharide of P. aeruginosacontains D-rhamnosylated O-antigen. The synthesis of GDP-D-rhamnose, the D-rhamnose donor in D-rhamnosylation, starts from GDP-D-mannose.
9p research12 23-04-2013 30 1 Download
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Salt-active acharan sulfate lyase (no EC number) has been purified fromBacteroides stercorisHJ-15,which was iso-lated from human intestinal bacteria with GAG degrading enzymes. The enzymewas purified toapparent homogeneity by a combination of QAE-cellulose,diethylaminoethyl (DEAE)-cellulose,CM-Sephadex C-50, HA ultrogel and phosphocellulose column chromatography with the final specific activity of 81.33lmolÆmin )1 Æmg )1 .
6p tumor12 20-04-2013 36 3 Download
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A large number of bioactive peptides have been isolated from amphibian skin secretions. These peptides have a variety of actions including antibiotic and anticancer acti-vities and the inhibition of neuronal nitric oxide synthase. We have investigated the structure–activity relationship of citropin 1.1, a broad-spectrum antibiotic and anticancer agent that also causes inhibition of neuronal nitric oxide synthase, by making a number of synthetically modified analogues.
13p tumor12 20-04-2013 37 3 Download
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Although highly controversial just a few years ago, the idea that G-pro-tein-coupled receptors (GPCRs) may undergo homo-oligomerization or hetero-oligomerization has recently gained considerable attention. The recognition that GPCRs may exhibit either dimeric or oligomeric structures is based on a number of different biochemical and biophysical approaches.
8p fptmusic 11-04-2013 50 2 Download
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Why are there so many dimeric proteins and enzymes? While for hetero-dimers a functional explanation seems quite reasonable, the case of homo-dimers is more puzzling. The number of homodimers found in all living organisms is rapidly increasing. A thorough inspection of the structural data from the available literature and stability (measured from denatura-tion–renaturation experiments)
0p awards 05-04-2013 39 1 Download
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Cytochrome P450 enzymes promote a number of oxidative biotransformations including the hydroxylation of unacti-vated hydrocarbons.
26p awards 05-04-2013 43 6 Download
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Glutamine is an essential amino acid in cancer cells and is required for the growth of many other cell types. Glutami-nase activity is positively correlated with malignancy in tumours andwith growth rate in normal cells. In the present work, Ehrlich ascites tumour cells, and their derivative, 0.28AS-2 cells, expressing antisense glutaminase mRNA, were assayed for apoptosis induced by methotrexate and hydrogen peroxide. It is shown that Ehrlich ascites tumour cells, expressing antisense mRNA for glutaminase, contain lower levels of glutathione than normal ascites cells. In addition, 0.
9p awards 05-04-2013 45 3 Download
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The Mycobacterium tuberculosisgenome contains an unusually high number of proteins involved in the metabo-lism of lipids belonging to the Lip family, including various nonlipolytic and lipolytic hydrolases. Driven by a structural genomic approach, we have biochemically characterized the Rv1399c gene product, LipH, previously annotated as a putative lipase. Rv1399c was overexpressed inE. colias inclusion bodies and refolded. Rv1399c efficiently hydro-lyzes soluble triacylglycerols and vinyl esters.
0p awards 05-04-2013 48 2 Download
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The structural stability of the large cytoplasmic domain (H4 -H5loop) of mouse a1subunit of Na + /K + ATPase (L354– I777), the number and the location of its binding sites for 2¢-3¢-O-(trinitrophenyl) adenosine 5¢-triphosphate (TNP-ATP) andp-nitrophenylphosphate (pNPP) were investi-gated. C- and N-terminal shortening revealed that neither part of the phosphorylation (P)-domain are necessary for TNP-ATP binding.
14p awards 05-04-2013 43 4 Download
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The dementia familial encephalopathy with neuroserpin inclusion bodies (FENIB) is caused by point mutations in the neuroserpin gene.We have shown a correlation between the predicted effect of the mutation and the number of intracerebral inclusions, and an inverse relationshipwith the age of onset of disease. Our previous work has shown that the intraneuronal inclusions in FENIB result from the sequential interactionbetween the reactive centre loopofone neuroserpin molecule withb-sheet A of the next. ...
0p awards 05-04-2013 29 2 Download
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The extracellular signal regulated protein kinases (ERK1/2) are essential for normal development and functional plasti-city of the central nervous system. However, a growing number of recent studies in models of cerebral ischemia, brain trauma and neurodegenerative diseases implicate a detrimental role for ERK1/2 signaling during oxidative neuronal injury. Neurons undergoing oxidative stress-rela-ted injuries typically display a biphasic or sustained pattern of ERK1/2 activation.
7p dell39 03-04-2013 39 2 Download
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The Alzheimer’s disease-linked amyloid-bprecursor pro-tein (APP) belongs to a superfamily of proteins, which also comprises the amyloid-b precursor-like proteins, APLP1 and APLP2. Whereas APP has been identified in both lower and higher vertebrates, thus far, APLP1 and 2 have been characterized only in human and rodents. Here we identify the first nonmammalian APLP2 protein in the South African claw-toed frogXenopus laevis.
7p dell39 03-04-2013 41 3 Download