Pancreatic tumor

This study was aimed at: (1) To describe the characteristics of the pancreatic tumor by endoscopic ultrasound; (2) To evaluate the efficacy and safety of endoscopic ultrasound fine needle aspiration in the diagnosis of pancreatic tumors.

7p viharuno 03-01-2025 4 2   Download

To present a case of recurrent hypoglycemia following Roux-en-Y gastric bypass (RYGB) surgery whose etiology was determined to be a proinsulin-predominant pancreatic neuroendocrine tumor (a proinsulinoma).

5p caothientrangnguyen 09-05-2020 15 3   Download

Amylin-mediated isletb-cell death is implicated in diabetogenesis. We pre-viously reported that fibrillogenic human amylin (hA) evokesb-cell apopto-sis through linked activation of Jun N-terminal kinase 1 (JNK 1) and a caspase cascade. Here we show that p38 kinase [p38 mitogen-activated pro-tein (MAP) kinase] became activated by hA treatment of cultured b-cells whereas extracellular signal-regulated kinase (ERK) did not;

13p inspiron33 25-03-2013 47 4   Download

Human amylin is a small fibrillogenic protein that is the major constituent of pancreatic islet amyloid, which occurs in most subjects with type 2 dia-betes. There is evidence that it can elicitin vitro apoptosis in isletb-cells, but the physical properties that underpin its cytotoxicity have not been clearly elucidated.

11p inspiron33 25-03-2013 43 5   Download

The crystal structure of human pancreatic cationic trypsin showed the chemical modification of Tyr154, which was originally described as phos-phorylation [Gaboriaud C, Serre L, Guy-Crotte O, Forest E & Fontecilla-Camps JC (1996)J Mol Biol259, 995–1010]. Here we report that Tyr154 is sulfated, not phosphorylated.

7p inspiron33 23-03-2013 28 4   Download

Chromosomal rearrangements apparently account for the presence of a pri-mate-specific gene (protease serine 3) in chromosome 9. This gene encodes, as the result of alternative splicing, both mesotrypsinogen and trypsino-gen 4. Whereas mesotrypsinogen is known to be a pancreatic protease, neither the chemical nature nor biological function of trypsinogen 4 has been explored previously.

11p galaxyss3 21-03-2013 44 4   Download

The ATP-sensitive potassium (KATP) channel couples glucose metabolism to insulin secretion in pancreatic b-cells. It comprises regulatory sulfonyl-urea receptor 1 and pore-forming Kir6.2 subunits. Binding and⁄or hydro-lysis of Mg-nucleotides at the nucleotide-binding domains of sulfonylurea receptor 1 stimulates channel opening and leads to membrane hyperpolari-zation and inhibition of insulin secretion.

13p galaxyss3 19-03-2013 49 4   Download

Expression of the tumor suppressor p16 INK4a after stable transfection can restore the susceptibility of epithelial tumor cells to anoikis. This property is linked to increases in the expression and cell-surface presence of the fibronectin receptor. Considering its glycan chains as pivotal signals, we assumed an effect of p16 INK4a on glycosylation.

24p galaxyss3 19-03-2013 35 5   Download

Trypsinogen-1 and -2 are well-characterized enzymes that are expressed in the pancreas and also in several other tissues. Many cancers produce tryp-sinogen isoenzymes that differ from the pancreatic ones with respect to substrate specificity and isoelectric point.

13p media19 05-03-2013 28 2   Download

Traditionally, the canine pancreatic endoplasmic reticulum (ER) has been the workhorse for cell-free studies on protein transport into the mamma-lian ER. These studies have revealed multiple roles for the major ER-lumi-nal heat shock protein (Hsp) 70, IgG heavy chain-binding protein (BiP), at least one of which also involves the second ER-luminal Hsp70, glucose-reg-ulated protein (Grp) 170.

13p media19 04-03-2013 34 3   Download

The tumor suppressor p16 INK4a has functions beyond cell-cycle control via cyclin-dependent kinases. A coordinated remodeling ofN- and O-glycosyla-tion, and an increase in the presentation of the endogenous lectin galectin-1 sensing these changes on the surface of p16 INK4a -expressing pancreatic carcinoma cells (Capan-1), lead to potent pro-anoikis signals.

12p viettel02 19-02-2013 60 4   Download

Onconase (ONC) is an amphibian member of the pancreatic ribonuclease superfamily that is selectively toxic to tumor cells. It is a much less efficient enzyme than the archetypal ribonuclease A and, in an attempt to gain fur-ther insight, we report the first atomic resolution crystal structure of ONC, determined in complex with sulfate ions at 100 K.

14p cosis54 09-12-2012 57 3   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Comparison between 68Ga-bombesin (68Ga-BZH3) and the cRGD tetramer 68Ga-RGD4 studies in an experimental nude rat model with a neuroendocrine pancreatic tumor cell line

23p dauphong5 04-01-2012 59 6   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Duodenal gastrointestinal stromal tumor resembling a pancreatic neuroendocrine tumor in a patient with neurofibromatosis type I (von Recklinghausen’s disease): a case report

4p toshiba25 09-12-2011 52 5   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Evolving Diagnostic and Treatment Strategies for Pancreatic Neuroendocrine Tumors...

8p thulanh25 06-12-2011 84 5   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Continuous and low-energy 125I seed irradiation changes DNA methyltransferases expression patterns and inhibits pancreatic cancer tumor growth

12p toshiba22 21-11-2011 79 5   Download

Background: Pancreatic cancer is one of the most aggressive human tumors due to its high potential of local invasion and metastasis. The aim of this study was to characterize the membrane proteomes of pancreatic ductal adenocarcinoma (PDAC) cells of primary and metastatic origins, and to identify potential target proteins related to metastasis of pancreatic cancer.

13p toshiba23 18-11-2011 81 3   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Surgical strategies for treatment of malignant pancreatic tumors: extended, standard or local surgery?

10p matuot_238 13-10-2011 74 3   Download

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Contrast-Enhanced Ultrasonograpic Findings in Pancreatic Tumors Chiara RECALDINI, Gianpaolo CARRAFIELLO, Elena BERTOLOTTI, Maria Gloria ANGERETTI, Carlo FUGAZZOLA...

6p thulanh8 06-10-2011 44 4   Download