Pathogenesis
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Stomach adenocarcinoma (STAD), which accounts for approximately 95% of gastric cancer types, is a malignancy cancer with high morbidity and mortality. Tumor angiogenesis plays important roles in the progression and pathogenesis of STAD, in which long noncoding RNAs (lncRNAs) have been verified to be crucial for angiogenesis.
14p vielonmusk 21-01-2022 9 0 Download
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To investigate biological roles of Myosin class I in the morphology of M. circinelloides and identify good candidates for further analyses of Mucor pathogenesis, we are going to inhibit their expression using RNAi technique. We named the two myosin class I like genes as M1L1 (ID 140500) and M1L2 (ID 116620). In the present study, we report the results of generation of RNAi plasmid to inhibit the expression of M1L1 gene.
6p koxih_kothogmih5 04-09-2020 33 2 Download
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Schistosomiasis is an endemic disease in Egypt caused by the trematode Schistosoma which has different species. c the best known form of chronic disease with a wide range of clinical manifestations. The pathogenesis of schistosomiasis is related to the host cellular immune response. This leads to granuloma formation and neo angiogenesis with subsequent periportal fibrosis manifested as portal hypertension, splenomegaly and esophageal varices. Intestinal schistosomiasis is another well identified form of chronic schistosomal affection.
8p kethamoi1 17-11-2019 27 0 Download
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LTP (Lipid Transfer Protein) thuộc họ gen pathogenesis relate, đƣợc xác định có liên quan với khả năng chịu hạn ở thực vật. Trong nghiên cứu này chúng tôi trình bày kết quả so sánh khả năng chịu hạn và phân lập gen LTP liên quan đến khả năng chịu hạn ở giống đậu xanh 044/ĐX06 và HN2.
7p cumeo2425 02-07-2018 78 3 Download
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Document "Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis" presentation of content: Epidemiology, pathogenesis and risk factors, diagnosis, management, summary, references.
29p vovanvovan2013 13-05-2016 62 1 Download
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Document presentation of content: Epidemiology and transmission of hepatitis B, pathogenesis and natural history, laboratory diagnosis of hepatitis B, long-term monitoring and screening of chronic hepatitis B, treatment for chronic hepatitis B, hepatitis B vaccination, automatic searches, guidelines, further reading, and web sites.
29p vovanvovan2013 13-05-2016 47 1 Download
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Document "Constipation: A global perspective" introduction of content: Cascades—a resource-sensitive approach, pathogenesis and risk factors, associated conditions and medication, diagnostic criteria for functional constipation, patient evaluation,... Invite you to consult.
13p vovanvovan2013 13-05-2016 35 2 Download
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In the course of trying to understand the pathogenesis of leishmaniasis in relation to extracellular matrix (ECM) elements, laminin, a major ECM protein, has been found to bind saturably and with high affinity to a 67-kDa cell surface protein of Leishmania donovani. This interaction involves a single class of binding sites, which are ionic in nature, conformation-dependent and possibly involves sulfhydryls. Binding activity was significantly enhanced by Zn2+, an effect possibly mediated through Cys-rich zinc finger-like sequences on laminin....
8p system191 01-06-2013 40 3 Download
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The immune coagulant fgl2/fibroleukin has been previously shown to play a pivotal role in the pathogenesis of murine and human fulminant hepatitis and fetal loss syndrome. Constitutive expression of fgl2 transcripts at low levels are seen in cytotoxic T cells, endothelial, intestinal and tropho-blast cells, while specific factors (such as virus and cytokines) are required to induce high levels of fgl2 expression in other cell types including monocytes/macrophages.
13p fptmusic 16-04-2013 34 3 Download
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Flexibacter maritimus, a Gram-negative bacterium, is a fish pathogenresponsible fordisease infinfishspecies andacause of cutaneous erosiondisease in sea-caged salmonids. For the development of serology based diagnostics, protective vac-cines, and a study of pathogenesis, the structural analysis of the lipopolysaccharide (LPS) producedby the bacteriumhas been undertaken. We now report that an acidic O-specific polysaccharide, obtained by mild acid degradation of the F. maritimusLPSwas found to be composed of a disac-...
6p fptmusic 16-04-2013 44 2 Download
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The Goodpasture antigen-binding protein, GPBP, is a serine⁄threonine kinase whose relative expression increases in autoimmune processes. Tumor necrosis factor (TNF) is a pro-inflammatory cytokine implicated in auto-immune pathogenesis. Here we show that COL4A3BP, the gene encoding GPBP, maps head-to-head withPOLK, the gene encoding for DNA polymerase kappa (polj), and shares with it a 140-bp promoter containing a Sp1 site, a TATA-like element, and a nuclear factor kappa B (NFjB)-like site
15p fptmusic 12-04-2013 35 2 Download
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Tobacco pathogenesis-related protein 1a (PR-1a) is induced in plants during the hypersensitive response (HR) after exposure of plants to salicylic acid (SA) and by develop-mental cues.Gene activation by these diverse stimuli is mediated via anas-1-like element in the PR-1aupstream region.To further analyze the significance of thiscis-acting sequence, an authentic as-1element from the cauliflower mosaic virus 35S RNA promoter was inserted into the PR-1apromoter in place of theas-1-like motif.
11p fptmusic 12-04-2013 33 2 Download
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The pathogenesis of formation of neurofibrillary tangles (NFTs) in Alzhei-mer’s disease (AD) brains is unknown. One of the possibilities might be that translation of tau mRNA is aberrantly regulated in AD brains.
10p fptmusic 11-04-2013 55 1 Download
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Fibrillization ofa-synuclein (a-Syn) is closely associated with the formation of Lewy bodies in neurons and dopamine (DA) is a potent inhibitor for the process, which is implicated in the causative pathogenesis of Parkin-son’s disease (PD). To elucidate any molecular mechanism that may have biological relevance, we tested the inhibitory abilities of DA and several analogs including chemically synthetic and natural polyphenols in vitro.
12p fptmusic 11-04-2013 42 2 Download
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Recently, a novel plaque-associated protein, collagenous Alzheimer amy-loid plaque component (CLAC), was identified in brains from patients with Alzheimer’s disease. CLAC is derived from a type II transmembrane colla-gen precursor protein, termed CLAC-P (collagen XXV). The biological function and the contribution of CLAC to the pathogenesis of Alzheimer’s disease and plaque formation are unknown.
0p awards 06-04-2013 26 1 Download
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Oxidative stress and imbalance between free radical generation and detoxi-fication may play a pivotal role in the pathogenesis of Leber’s hereditary optic neuropathy (LHON). Mitochondria, carrying the homoplasmic 11778⁄ND4, 3460⁄ND1 and 14484⁄ND6 mtDNA point mutations associ-ated with LHON, were used to generate osteosarcoma-derived cybrids. Enhanced mitochondrial production of reactive oxygen species has recently been demonstrated in these cybrids [Beretta S, Mattavelli L, Sala G, Trem-olizzo L, Schapira AHV, Martinuzzi A, Carelli V & Ferrarese C (2004) Brain127, 2183–2192]. ...
0p awards 05-04-2013 42 3 Download
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The urea cycle enzyme arginase (EC 3.5.3.1) hydrolyzes L-arginine to L-ornithine and urea. Mammalian arginases require manganese, have a highly alkaline pH optimum and are resistant to reducing agents. The gastric human pathogen,Helicobacter pylori, also has a complete urea cycle and contains therocFgene encoding arginase (RocF), which is involved in the pathogenesis ofH. pyloriinfection. Its arginase is specifically involved in acid resistance and inhibits host nitric oxide production.
11p dell39 03-04-2013 48 4 Download
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Programmed cell death is a major component of both normal development and disease. The roles of cell death during either embryogenesis or pathogenesis, the signals that modulate this event, and the mechanisms of cell demise are the major subjects that drive research in this field. Increasing evidence obtained both in vitro and in vivo supports the hypothesis that a variety of cell death programs maybe triggered in distinct circumstances.
13p dell39 03-04-2013 41 4 Download
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Homocysteine (Hcy) is anonprotein-forming sulphur amino acid that plays an important role in remethylation and trans-sulphuration processes. In recent years, it has been suggested that increased levels of plasma Hcy may play a role in the pathogenesis of various diseases, particularly at the cardiovascular level. The pathogenic mechanism of hyperhomocysteinemia, however, has not been clarified.
6p dell39 03-04-2013 52 2 Download
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Ouabain, a sodiumpump (Na + /K + -ATPase) inhibitor, has been shown to act as a hormone and is possibly involved in the pathogenesis of hypertension. The mechanismby which ouabain may act was investigated using primary cultures of human umbilical artery endothelial cells (HUAECs), which are known to express and release the vasoconstrictive hor-mone endothelin (ET-1). Fiveminutes after application, low concentrations of ouabain induced Ca 2+ oscillations and stimulated ET-1 release from endothelial cells into the medium.
9p dell39 03-04-2013 33 4 Download