Peptide hormones

To survey fasting plasma glucagon-like peptide-1 concentrations in newly-diagnosed type 2 diabetes mellitus patients having overweight or obese status. Subjects and methods: A cross-sectional descriptive study on 92 subjects, divided into 3 groups.

8p viengfa 28-10-2024 3 2   Download

Tài liệu "Thuốc nội tiết" nhằm giúp học viên trình bày được định nghĩa, vai trò, đặc điểm, phân loại hormon; nêu được tác dụng chung, chỉ định và nguyên tắc sử dụng glucocorticoid; trình bày được nguồn gốc tính chất, tác dụng, chỉ định, chống chỉ định, cách dùng, bảo quản các hormon và các dẫn chất tổng hợp dùng làm thuốc đã học. Mời các bạn cùng tham khảo!

17p quyvanphi 28-03-2025 2 1   Download

Incretin là những hormone peptide được tiết ra từ ruột qua kích thích của thức ăn. Chúng làm tăng tiết insulin. Đáp ứng tiết incretin bị giảm ở bệnh nhân ĐTĐ týp 2, như thế các thuốc tác động lên incretin có thể cải thiện sự kiểm soát glucose huyết. Bài viết Incretin và bệnh đái tháo đường trình bày các nội dung: Đại cương về Incretin và bệnh đái tháo đường; Các loại incretin và tác dụng; Các loại incretin và tác dụng.

7p viuchiha 06-01-2025 5 1   Download

Hiệu lực phụ thuộc vào:Tốc độ tổng hợp và bài tiết Vận chuyển trong huyết tương Receptor. VD ĐTĐ type II do giảm receptor của Insulin Tốc độ thoái hóa Nồng độ thấp: 10-10–10-12 mol (peptid),

50p fpt_12 21-05-2013 147 18   Download

Mục tiêu chính của bài giảng nhằm giúp các bạn Trình bày các loại hormon theo cấu tạo hóa học và cơ chế tác dụng, viết được cấu tạo hóa học và tác dụng chính các hormon có bản chất peptid và protein, vẽ sơ đồ quá trình tổng hợp, thoái hóa hormon tuyến giáp trạng và tủy thượng thận, viết được cấu tạo hóa học, tên các hormon steroid điển hình.

81p ninhhuong1104 03-01-2018 360 51   Download

Hepcidin (H25) is a hormone peptide synthesized by the liver that binds to ferroportin and blocks iron export. In this study, H25 was inhibited by administration of single and multiple doses of an anti-H25 monoclonal antibody Ab 12B9m in cynomolgus monkeys. The objective of this analysis was to develop a pharmacodynamic model describing the role of H25 in regulating iron homeostasis and the impact of hepcidin inhibition by Ab 12B9m. Total serum H25 and Ab 12B9m were determined in each animal. Corresponding measurements of serum iron and hemoglobin (Hb) were obtained.

15p caothientrangnguyen 09-05-2020 14 1   Download

p 01-01-1970   Download

The plastid transcription kinase (PTK), a component of the major RNA polymerase complex from mustard chloroplasts, has been implicated in redox-mediated regulation of plastid gene expression. A cloning strategy to define the PTK gene(s) resulted in the isolation of a full-length cDNA for a protein with overall high homology with the a subunit of cytosolic casein kinase (CK2) that contained an N-terminal extension for a putative plastid transit peptide.

9p system191 01-06-2013 49 4   Download

Calcitonin (Ct) is a 32-residue peptide hormone that is mainly known for its hypocalcemic effect and the inhibition of bone resorption. Our previous studies have led to potent, side-chain lactam-bridged human Ct (hCt) analogues [Kapurniotu, A. Kayed, R., Taylor, J.W. & Voelter W. (1999) Eur. J. Biochem.265, 606±618; Kapurniotu, A. & Taylor, J.W. (1995)J. Med. Chem.38, 836±847]. We have hypothesized that a possibly type Ibturn/bsheet confor-mation in the region 17±21 may play an important role in hCt bioactivity. ...

12p research12 01-06-2013 48 5   Download

Recently, we identified novel avian and amphibian hypothalamic neuropeptides that inhibited gonadotropin release and stimulated growth hormone release. They were characterized by a similar structure including theC-terminal LPLRF-NH2motif. To clarify that the expression of these novel hypothalamicneuropeptides is aconservedproperty in vertebrates, we characterized a cDNA encoding a similar novel peptide, having LPLRF-NH2 from the goldfish brain, by a combination of 3¢and 5¢rapid amplification of cDNA ends (RACE). ...

9p research12 29-04-2013 43 4   Download

Two neuropeptides have been isolated and identi®ed from the secretions of the skin glands of the Stony Creek Frog Litoria lesueuri. The ®rst of these, the known neuropeptide caerulein 1.1, is a common constituent of anuran skin secretions, and has the sequence pEQY(SO3 )TGWMDF-NH2 . This neuropeptide is smooth muscle active, an anal-gaesic more potent thanmorphine and is also thought to be a hormone.

10p research12 29-04-2013 42 3   Download

Structurally tachykinin-related peptides have been isolated fromvarious invertebrate species and shown to exhibit their biological activities through a G-protein-coupled receptor (GPCR) for a tachykinin-related peptide. In this paper, we report the identification of a novel tachykinin-related pep-tide receptor, the urechistachykinin receptor (UTKR) from the echiuroidworm,Urechis unitinctus.

9p research12 23-04-2013 26 2   Download

A new human/rat CRH analogue has been synthesized using the Fmoc/tBu solid-phase synthetic protocol. The sequence ofthe new peptide differs from the original in two positions, 12 and 15, at which the native amino acids L-phenylalanine 12 and L-leucine 15 have been replaced by the nonprotein amino acids D-phenylalanine and a-aminoisobutyric acid (Aib), respectively. The high resolution three-dimensional solution structure of [D-Phe12, Aib15]CRH has been determined by 688 dis-tance constraints (656 meaningful NOE and 32 H-bonds distance limits) and 21 angle constraints. ...

11p tumor12 22-04-2013 38 3   Download

Thea-phycoerythrocyanin subunits of the different phy-coerythrocyanin complexes of the phycobilisomes from the cyanobacterium Mastigocladus laminosusperform a remarkable photochemistry. Similar to phytochromes – the photoreceptors of higher plants – the spectral pro-perties of the molecule reversibly change according to the irradiation wavelength. To enable extensive analyses,the protein has been produced at high yield by improving purification protocols.

10p tumor12 22-04-2013 49 3   Download

Theb-amyloid peptide (Ab) is a major component of toxic amyloid plaques found in the brains of patients with Alzheimer’s disease.Abis liberated by sequential cleavage of amyloid precursor protein (APP) byb-andc-secre-tases.The level of Abdepends directly on the hydrolytic activity ofb-secretase.Therefore, b-secretase is an excel-lent target for drug design.An approach based on RNA-cleaving ribozymes was developed to control expression ofb-secretase.

9p tumor12 20-04-2013 39 4   Download

Liquid chromatography mass spectrometry (LC-MS) is a valuable tool in the analysis of proteins and peptides.The combination of LC-MS with different fragmentation methods provides sequence information on components in complex mixtures.In this work, on-line packed capillary LC electrospray ionization Fourier transform ion cyclotron resonance MS was combined with two complementary fragmentation techniques, i.e.

7p tumor12 20-04-2013 50 2   Download

Glucagon-like peptide-2 (GLP-2) is a potent intestino-trophic/satiety hormone that acts through a G protein-coupled receptor. To determine whether or not GLP-2 has any effect on cellular proliferation on neural cells,we examined the effects of this peptide on cultured astrocytes from rat cerebral cortex. The expression of the GLP-2 receptor gene in both cerebral cortex and astrocytes was determined by RT-PCR and Southern blotting. Also,cells responded toGLP-2,producing cAMP in a dose-dependent manner (EC50¼0.86 nM)....

9p fptmusic 16-04-2013 48 2   Download

Soybean 4-kDa peptide, a hormone-like peptide, is a ligand for the 43-kDaprotein in legumes that functions as aprotein kinase and controls cell proliferation and differentiation. As this peptide stimulates proteinkinase activity, the interaction between the 4-kDa peptide (leginsulin) and the 43-kDa protein is considered important for signal transduction. However, the mechanism of interaction between the 4-kDa peptide and the 43-kDa protein is not clearly understood.

10p fptmusic 16-04-2013 37 3   Download

The peptide hormone endothelin transmits various signals throughGprotein-coupled receptors, the endothelin type A (ETAR) and B (ETBR) receptors. Caveolae are specialized lipid rafts containing polymerized caveolins. We examined the interaction of ETBR with caveolin-1, expressed in Sf9, COS-1, and HEK293 cells, and its effects on the subcellular distribution and the signal transduction of ETBR.

12p fptmusic 16-04-2013 28 2   Download

Defining how the agonist–receptor interaction differs from that of the antagonist–receptor and understanding the mechanisms of receptor activation are fundamental issues in cell signalling. The V1a vasopressin receptor (V1aR) is a member of a family of related G-protein coupled receptors that are activated by neurohypophysial peptide hormones, including vasopressin (AVP). It has recently been reported that anarginyl in the distalN-terminus of theV1a Riscritical for binding agonists but not antagonists....

8p fptmusic 12-04-2013 30 2   Download