Physiological and pathological processes

Transcripts with alternative 5′-untranslated regions (UTRs) result from the activity of alternative promoters and they can determine gene expression by influencing its stability and translational efficiency, thus executing complex regulation of developmental, physiological and pathological processes.

9p vielonmusk 21-01-2022 10 0   Download

Levels of deoxyribonuclease I (DNase I) activityin vivo have been shown to be altered by physiological and⁄or pathological processes. However, no information is available on the regulation of DNase I gene (DNASE1) expressionin vivo orin vitro. We first mapped the transcription start sites ofDNASE1in human pancreas and in the DNase I-producing human pan-creatic cancer cell line QGP-1, and revealed a novel site
12 kb upstream of exon 1, which was previously believed to be the single transcription-starting exon. ...

12p inspiron33 25-03-2013 35 2   Download

Prolyl oligopeptidase (POP) is a serine protease that cleaves small peptides at the carboxyl side of an internal proline residue. Substance P, arginine– vasopressin, thyroliberin and gonadoliberin are proposed physiological substrates of this protease. POP has been implicated in a variety of brain processes, including learning, memory, and mood regulation, as well as in pathologies such as neurodegeneration, hypertension, and psychiatric disor-ders.

13p galaxyss3 07-03-2013 40 3   Download

Docking proteins comprise a distinct category of intracellular, noncatalytic signalling protein, that function downstream of a variety of receptor and receptor-associated tyrosine kinases and regulate diverse physiological and pathological processes.

14p viettel02 19-02-2013 37 3   Download

The serine endopeptidase elastase-2 from human polymorphonuclear leu-kocytes is associated with physiological remodeling and pathological deg-radation of the extracellular matrix. Glycosaminoglycans bound to the matrix or released after proteolytic processing of the core proteins of pro-teoglycans are potential ligands of elastase-2.

10p mobifone23 21-01-2013 54 4   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Involvement of microRNAs in physiological and pathological processes in the lung...

10p toshiba11 19-10-2011 55 3   Download

The central mechanism of DIC is the uncontrolled generation of thrombin by exposure of the blood to pathologic levels of tissue factor (Fig. 110-3). Simultaneous suppression of physiologic anticoagulant mechanisms and abnormal fibrinolysis further accelerate the process. Together these abnormalities contribute to systemic fibrin deposition in small and mid-sized vessels. The duration and intensity of the fibrin deposition can compromise the blood supply of many organs, especially the lung, kidney, liver, and brain, with consequent organ failure.

5p thanhongan 07-12-2010 65 3   Download