Synthesis and anticancer

A fragment-based approach has been applied to derive 2-(7-hydroxy-2-oxo-2H-chromen-4- yl)acetic acid 1 into 4 new coumarin derivatives 2a-d through amide bonds. The compounds were screened for their anticancer activity using MTT assay on MCF-7 and HepG2 cell lines.

10p viaburame 14-03-2025 4 0   Download

A benzothiazole ring plays an important role in pharmacological target diseases, including metabolic diseases, cancer, anti-inflammatory, neurodegeneration, viral diseases, bacterial infections, fibrosis, and thrombosis. Hydrazone-hydrazide derivatives are present in numerous biological molecules and play a significant role in medicine and pharmacology.

9p viaburame 14-03-2025 2 1   Download

Aim of the thesis: Synthesis of several derivatives and tubulysin analogues with the replacement of the amino acid methylpipecolic (Mep) at the N-terminal, replacing N,O-acetyl group by methyl group, and researching the role of tubuphenylalanine (Tup) group at the C-terminal.

26p extraenglish 24-05-2021 18 4   Download

Objective: Study on synthesis of nano dendrimer PAMAM with anticancer drugs carboplatin (CAR) and oxaliplatin (OXA) to reduce the toxicity of the drug to normal cells and improve the effectiveness on cancer cell destruction by increasing solubility, increasing drug storage capacity, targeting drugs passively.

27p extraenglish 24-05-2021 24 4   Download

Synthesis of several derivatives and tubulysin analogues with the replacement of the amino acid methylpipecolic (Mep) at the N-terminal, replacing N,O-acetyl group by methyl group, and researching the role of tubuphenylalanine (Tup) group at the C-terminal .

26p capheviahe27 23-02-2021 20 5   Download

Obtained by the interaction of 2-amino-3,3-dichloroacrylonitrile and chlorosulphonyl isocyanate (Z)-(5-(dichloromethylene)-2-oxoimidazolidin-4-ylidene)sulfamoyl chloride reacts easily with excess of the aliphatic amine to form new (Z)-N-(5-(dichloromethylene)-2-oxoimidazolidin-4-ylidene)-N'-substituted sulfonamides.

12p tocectocec 25-05-2020 11 2   Download