Vasodilators

Cytosolic phospholipase A2-a(cPLA2-a) is a calcium-activated enzyme that plays an important role in agonist-induced arachidonic acid release. In endothelial cells, free arachidonic acid can be converted subsequently into prostacyclin, a potent vasodilator and inhibitor of platelet activation, through the action of cyclooxygenase (COX) enzymes. Here we study the relocation of cPLA2 -a in human EA.hy.926 endothelial cells following stimulation with the calcium-mobilizing agonist, A23187.

13p awards 06-04-2013 38 3   Download

Palladin is an actin-associated protein that has been suggested to play crit-ical roles in establishing cell morphology and maintaining cytoskeletal organization in a wide variety of cell types. Palladin has been shown previ-ously to bind directly to three different actin-binding proteins vasodilator-stimulated phosphoprotein (VASP), a-actinin and ezrin, suggesting that it functions as an organizing unit that recruits actin-regulatory proteins to specific subcellular sites.

8p dell39 27-03-2013 43 3   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Renal hypoperfusion and impaired endothelium-dependent vasodilation in an animal model of VILI: the role of the peroxynitrite-PARP pathway...

10p coxanh_6 30-10-2011 53 2   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Alterations in vasodilator-stimulated phosphoprotein (VASP) phosphorylation: associations with asthmatic phenotype, airway inflammation and β2-agonist use...

9p toshiba13 21-10-2011 43 3   Download