
Báo cáo khoa học: Proteoglycans in health and disease: novel roles for proteoglycans in malignancy and their pharmacological targeting
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The expression of proteoglycans (PGs), essential macromolecules of the tumor microenvironment, is markedly altered during malignant transforma-tion and tumor progression. Synthesis of stromal PGs is affected by factors secreted by cancer cells and the unique tumor-modified extracellular matrix may either facilitate or counteract the growth of solid tumors.
Chủ đề:
- Scientific reports
- scientific research
- biochemistry
- The expression of proteoglycans (PGs)
- essential macromolecules of the tumor microenvironment
- is markedly altered during malignant transforma-tion and tumor progression. Synthesis of stromal PGs is affected by factors secreted by cancer cells and the unique tumor-modified extracellular matrix may either facilitate or counteract the growth of solid tumors.
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