
The expression of proteoglycans (pgs)
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Madin–Darby canine kidney (MDCK) cells, which do not normally express the proteoglycan (PG) serglycin, were stably transfected with cDNA for human serglycin fused to a polyhistidine tag (His-tag). Clones with differ-ent levels of serglycin mRNA expression were generated. One clone with lower and one with higher serglycin mRNA expression were selected for this study.
12p
dell39
27-03-2013
42
4
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The expression of proteoglycans (PGs), essential macromolecules of the tumor microenvironment, is markedly altered during malignant transforma-tion and tumor progression. Synthesis of stromal PGs is affected by factors secreted by cancer cells and the unique tumor-modified extracellular matrix may either facilitate or counteract the growth of solid tumors.
20p
viettel02
19-02-2013
54
4
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