Inhibitors

Hereditary angioedema (HAE) is a rare autosomal dominant disease, characterized by recurrence swelling of the skin or mucosal tissue, and may cause airway obstruction. It is caused by C1-esterase inhibitor (C1-INH) deficiency, or dysfunction of C1-INH, therefore increased bradykinin and kallikrein production, which causes vasodilation, increases vascular permeability and localized fluid extravasation results in angioedema.

4p vihizuzen 26-05-2025 3 1   Download

Levofloxacin (LEV) is the common quinolone antibiotic and a practical option in H. pylori eradication regimens. The LEV resistance can be acquired through variant sequences of a gyrA. This study investigated the correlation between gyrA genetic diversity and LEV resistance in H. pylori.

7p vihizuzen 26-05-2025 1 1   Download

The images of diffuse lung involvement are seen in various respiratory diseases, including lung adenocarcinoma (ADC). After ruling out acute infectious causes, lung biopsy is valuable for a definitive diagnosis, with transbronchial biopsy via flexible bronchoscopy being an effective and safe diagnostic approach.

8p vimitsuki 06-05-2025 3 1   Download

Tài liệu hướng dẫn quy trình kỹ thuật "Định lượng C-Esterase Inhibitor máu" thông tin đến bạn đọc những nội dung về: nguyên lý, chuẩn bị phương tiện - hóa chất, phiếu xét nghiệm, các bước tiến hành, nhận định kết quả, những sai sót và xử trí,... Mời các bạn cùng tham khảo!

2p thammduongg 27-04-2025 1 1   Download

Medicines in the DPP4 inhibitor class include sitagliptin, saxagliptin, linagliptin, and alogliptin. However, research data on the mechanism of action of the active ingredients of WBG on DPP4 are also limited. Therefore, this in silico study aimed to idenfy acve ingredients with strong or potential effects on the DPP4 target for andiabec acvity of WBG.

8p viling 11-10-2024 5 1   Download

A novel series of s-triazine derivatives was designed and screened for in silico an cancer activity in histone deacetylase 6 (HDAC6) target by molecular docking method using AutoDock Vina.

10p vifilm 11-10-2024 3 1   Download

The study's purpose is to in silico molecular docking of some new s-triazine derivatives for anticancer activity on the VEGFR2 receptor. Fifty s-triazine derivatives were screened for anticancer activity through inhibition of VEGFR2 (vascular endothelial growth factor receptor-2) by molecular docking method using AutoDock Vina software.

10p vifilm 11-10-2024 1 1   Download

Bài viết trình bày đánh giá một số tác dụng phụ và phân tích mối liên quan với việc tuân thủ điều trị Aromatase Inhibitor (AIs) trên bệnh nhân ung thư vú có thụ thể nội tiết dương tính. Đối tượng và phương pháp: Bằng phương pháp mô tả trên 234 bệnh nhân ung thư vú có thụ thể nội tiết dương tính được điều trị nội tiết bậc 2 tại Bệnh viện Trung ương thái Nguyên.

5p vibenya 23-10-2024 7 2   Download

This study aims to further characterize LN as a potential inhibitor of α-glucosidase and α-amylase and its high possibility of being developed as an antidiabetic drug via in silico studies.

8p viengfa 28-10-2024 1 1   Download

Bài viết trình bày Imatinib mesylate (IM) là thuốc ức chế tyrosin kinase (tyrosine kinase inhibitors-TKIs) thế hệ đầu tiên đã chứng minh được hiệu quả điều trị bệnh bạch cầu mạn dòng tủy (BCMDT). Tuy nhiên, khoảng 27% người bệnh (NB) đã xuất hiện đề kháng với IM sau một thời gian sử dụng. Tỷ lệ NB không dung nạp IM phải ngưng thuốc mặc dù có thấp hơn nhưng cũng gây một khó khăn không nhỏ trong quá trình điều trị.

8p viciize 27-11-2024 3 2   Download

A fragment-based approach has been applied to derive 2-(7-hydroxy-2-oxo-2H-chromen-4- yl)acetic acid 1 into 4 new coumarin derivatives 2a-d through amide bonds. The compounds were screened for their anticancer activity using MTT assay on MCF-7 and HepG2 cell lines.

10p viaburame 14-03-2025 4 0   Download

In this study, 2D-QSAR analysis and molecular docking were performed to investigate the relationship between the hydroxamatebased HDAC inhibitors with benzimidazole scaffold and the activity toward HDAC6. A dataset of 55 N-hydroxybenzamide, Nhydroxypropenamide derivatives containing benzimidazole structure with HDAC6 in vitro activity were collected.

8p vihyuga 04-03-2025 3 1   Download

Acetylcholinesterase (AChE) has been one of the important and potential targets in the discovery, and development of new drugs for treating and slowing the progression of Alzheimer's disease (AD). This research suggests potential structural frameworks for synthesizing AChE inhibitor derivatives for treating AD.

11p vihyuga 04-03-2025 1 1   Download

This study aimed to design novel Glutaminyl Cyclase (QC) inhibitors based on 2D-QSAR study, ligand-based pharmacophore modeling and molecular docking. A 2D-QSAR model was developed from a dataset of 1681 QC inhibitors by using Support Vector Regression (SVR) algorithm with 256-bit Morgan fingerprints.

17p vihyuga 04-03-2025 7 1   Download

Acetylcholinesterase (AChE) is a key therapeutic target for developing new Alzheimer's disease (AD) treatments due to its regulatory function in acetylcholine hydrolysis. This research contributed to the development of a novel scaffold for AChE inhibitors, which are potential drugs for treating AD.

17p vihyuga 04-03-2025 5 1   Download

Psoriatic arthritis (PsA) is a chronic, systemic inflammatory disease. This study assessed the cost-effectiveness of secukinumab, an interleukin-17A inhibitor, versus standard of care (SoC) from Vietnam’s National Health Insurance (NHI) perspective. Model-based cost-effectiveness analysis, the structure was a 3-month decision tree leading into a Markov model.

10p vihyuga 04-03-2025 6 1   Download

Bài viết này nhằm cung cấp thêm dữ liệu có tính khoa học về tình trạng tăng cường methyl hóa trong vùng promoter trên đảo CpG của bệnh nhân mắc ung thư vòm họng dựa trên việc phân tích gene p16INK4α bằng phương pháp tổng hợp thống kê.

10p tuetuebinhan000 23-01-2025 1 0   Download

Helicobacter pylori is a bacterium associated with gastric diseases and disorders of the upper gastrointestinal tract. The gram-negative bacterium Helicobacter pylori is known as a persistent colonizer of the human stomach, and this bacteria is also involved in extra-intestinal diseases. In 1994, the International Agency for Research on Cancer, World Health Organization classified H. pylori as a class 1 carcinogen, the only bacterium given this classification.

11p vinara 11-01-2025 2 1   Download

Helicobacter pylori (H.pylori) associated chronic gastritis is a risk factor of gastric cancer. This study aims to confirm effect of H.pylori eradication of sequential therapy (RA-RCT) and compare with the standard triple-drug therapy (RCT), addition to evaluating the improvement about histology of chronic gastritis after treatment.

7p viuchiha 06-01-2025 6 1   Download

Colorectal cancer (CRC) is one of the most common malignant cancers of the colon worldwide. Several novel approaches to cancer treatment have emerged, including gene therapy, targeted therapy, and adjuvant therapies.

7p viharuno 03-01-2025 6 2   Download