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Báo cáo khoa học: A differential scanning calorimetry study of tetracycline repressor

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:10

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Tetracycline repressor (TetR), which constitutes the most commonmechanismof bacterial resistance to an antibiotic, is a homodimeric protein composed of two identical sub-units, each of which contains a domain possessing a helix– turn–helix motif and a domain responsible for binding tetra-cycline. Binding of tetracycline in the protein pocket is accompanied by conformational changes in TetR, which abolish the specific interaction between the protein and DNA.

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Nội dung Text: Báo cáo khoa học: A differential scanning calorimetry study of tetracycline repressor

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