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Báo cáo khóa học: Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:11

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The presenilin proteins are required for intramembrane cleavage of a subset of type 1 membrane proteins including the Alzheimer’s disease amyloid precursor protein. Previous studies indicate presenilin proteins form enzymatically act-ive high molecular mass complexes consisting of hetero-dimers of N- and C-terminal fragments in association with nicastrin, presenilin enhancer-2 and anterior pharynx defective-1 proteins.

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Nội dung Text: Báo cáo khóa học: Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations

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