Báo cáo khoa học: Glycolipids with nonreducing end a-mannosyl residues that have the potential to activate invariant Va19 NKT cells

We have previously demonstrated thata-mannosyl ceramide and its deriva-tives promote immune responses of NK1.1 + invariant Va19-Ja33 T cell receptor (TCR) a + T cells (Va19 NKT cells). In this study, attempts were made to determine the structural requirements for natural ligands for Va19 NKT cells.