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Báo cáo khoa học: Mapping of the active site of glutamate carboxypeptidase II by site-directed mutagenesis

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:11

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Human glutamate carboxypeptidase II [GCPII (EC 3.4.17.21)] is recog-nized as a promising pharmacological target for the treatment and imaging of various pathologies, including neurological disorders and prostate can-cer. Recently reported crystal structures of GCPII provide structural insight into the organization of the substrate binding cavity and highlight residues implicated in substrate⁄inhibitor binding in the S1¢ site of the enzyme.

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Nội dung Text: Báo cáo khoa học: Mapping of the active site of glutamate carboxypeptidase II by site-directed mutagenesis

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