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Báo cáo khoa học: Mechanism of binding of serum response factor to serum response element

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:15

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Serum response factor (SRF) is a MADS transcription factor that binds to the CArG box sequence of the serum response element (SRE). Through its binding to CArG sequences, SRF activates several muscle-specific genes as well as genes that respond to mitogens. The thermodynamic parameters of the interaction of core-SRF (the 124–245 fragment of serum response fac-tor) with specific oligonucleotides from c-fos anddesminpromoters, were determined by spectroscopy.

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