
Báo cáo khoa học: Mutational analysis of plasminogen activator inhibitor-1 Interactions of a-helix F and its neighbouring structural elements regulates the activity and the rate of latency transition
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The serpin plasminogen activator inhibitor-1 (PAI-1) is a fast and specific inhibitor of the plasminogen activating serine proteases tissue-type and urokinase-type plasminogen activator and, as such, an important regulator in turnover of extracellularmatrixand infibrinolysis. PAI-1 spontaneously loses its antiproteolyticactivityby inserting its reactive centre loop (RCL) as strand 4 in b-sheet A, thereby converting to the so-called latent state.
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