Báo cáo khoa học: R120G aB-crystallin promotes the unfolding of reduced a-lactalbumin and is inherently unstable

a-Crystallin is the principal lens protein which, in addition to its structural role, also acts as a molecular chaperone, to prevent aggregation and preci-pitation of other lens proteins. One of its two subunits,aB-crystallin, is also expressed in many nonlenticular tissues, and a natural missense muta-tion, R120G, has been associated with cataract and desmin-related myopa-