Báo cáo khoa học: Reductive nitrosylation and peroxynitrite-mediated oxidation of heme–hemopexin

Hemopexin (HPX), which serves as a scavenger and transporter of toxic plasma heme, has been postulated to play a key role in the homeostasis of NO. In fact, HPX–heme(II) reversibly binds NO and facilitates NO scaven-ging by O2. HPX–heme is formed by two four-bladed b-propeller domains. The heme is bound between the twob-propeller domains, residues His213 and His266 coordinate the heme iron atom.