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Báo cáo khoa học: Structure, epitope mapping, and docking simulation of a gibberellin mimic peptide as a peptidyl mimotope for a hydrophobic ligand

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:11

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Using NMR spectroscopy and simulated annealing calculations, we deter-mined the solution structure of the disulfide-linked cyclized decapeptide ACLPWSDGPC (SD), which is bound to an anti-(gibberellin A4) mAb 4-B8(8)⁄E9 and was found to be the first peptidyl mimotope for a hydro-phobic ligand. The resulting structure of the peptide showed ab-turn-like conformation in residues three to seven and the region converges well (average rmsd 0.54 A ˚ ).

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Nội dung Text: Báo cáo khoa học: Structure, epitope mapping, and docking simulation of a gibberellin mimic peptide as a peptidyl mimotope for a hydrophobic ligand

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