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Báo cáo khoa học: Upstream and intronic regulatory sequences interact in the activation of the glutamine synthetase promoter

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:7

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Glutamine synthetase (GS) is expressed at high levels in subsets of cells in some tissues and at low levels in all cells of other tissues, suggesting that the GS gene is surrounded by multiple regulatory elements.We searched for such elements in the 2.5-kbupstreamregionand in the 2.6-kbfirst intronof theGSgene, usingFTO-2Bhepatoma andC2/7muscle cells as representatives of both cell types and transient transfec-tion assays as our tools.

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Nội dung Text: Báo cáo khoa học: Upstream and intronic regulatory sequences interact in the activation of the glutamine synthetase promoter

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