intTypePromotion=1
zunia.vn Tuyển sinh 2024 dành cho Gen-Z zunia.vn zunia.vn
ADSENSE

Báo cáo Y học: Stabilization of a (ba)8-barrel protein by an engineered disulfide bridge

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:9

38
lượt xem
4
download
 
  Download Vui lòng tải xuống để xem tài liệu đầy đủ

The aim of this study was to increase the stability of the thermolabile (ba)8-barrel enzyme indoleglycerol phosphate synthase from Escherichia coli by the introduction of disulfide bridges. For the design of such variants, we selected two out of 12 candidates, in which newly introduced cysteines potentially form optimal disulfide bonds. These variants avoid short-range connections, substitutions near catalytic residues, and crosslinks between the new and the three parental cysteines.

Chủ đề:
Lưu

Nội dung Text: Báo cáo Y học: Stabilization of a (ba)8-barrel protein by an engineered disulfide bridge

ADSENSE

CÓ THỂ BẠN MUỐN DOWNLOAD

 

Đồng bộ tài khoản
6=>0