Calcium-sensing receptor mediates phenylalanine-induced cholecystokinin secretion in enteroendocrine STC-1 cellsTohru Hira1, Shingo Nakajima2, Yuzuru Eto3 and Hiroshi Hara11 Division of Applied Biosciences, Research Faculty of Agriculture, Hokkaido Univ

Intraluminall-phenylalanine (Phe) stimulates cholecystokinin (CCK) secre-tion in vivo andin vitro. However, the cellular mechanism by which CCK-producing enteroendocrine cells sense Phe is unknown. The calcium-sensing receptor (CaR) can sense amino acids, and is expressed in the gastrointesti-nal tract.