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Báo cáo khoa học: Comparison of the solution structures of angiotensin I & II Implication for structure-function relationship

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:11

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Conformational analysis of angiotensin I (AI) and II (AII) peptides has been performed through 2D 1 H-NMRspectro-scopy in dimethylsulfoxide and 2,2,2-trifluoroethanol/H2 O. The solution structural models of AI and AII have been determined in dimethylsulfoxide using NOE distance and 3 JHNHacoupling constants. Finally, theAI family of models resulting from restrained energy minimization (REM) refinement, exhibits pairwise rmsd values for the family ensemble 0.26 ± 0.13 A ˚,1.05 ± 0.23 A ˚, for backbone and heavy atoms, respectively, and the distance penalty function is calculated at 0.075 ± 0.006 A ˚ 2 . ...

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