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Báo cáo khoa học: Identification of CD4 and transferrin receptor antibodies by CXCR4 antibody-guided Pathfinder selection

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:10

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To generate human antibodies against CXCR4, a seven-transmembrane chemokine receptor and a principal coreceptor forHIV-1, several roundsofPathfinder andStep-back selection from a large phage display antibody library were performed on Jurkat cells. A mAb against CXCR4 or biotinyated phage antibodies were used as guide molecules. Over 100 pan-Jurkat-cell-positive antibodies were charac-terized, but none were CXCR4 specific.

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Nội dung Text: Báo cáo khoa học: Identification of CD4 and transferrin receptor antibodies by CXCR4 antibody-guided Pathfinder selection

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